Acute hyperglycemia and acute hyperinsulinemia decrease plasma fibrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat
Acute hyperglycemia and acute hyperinsulinemia decrease plasma fibrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat
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DOI：
10.1007/s005920170016
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发表时间：
2001-06-01
影响因子：
3.8
通讯作者：
Consoli, A
中科院分区：
文献类型：
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作者：
Pandolfi, A;Giaccari, A;Consoli, A
血浆纤维蛋白溶解降低可能导致糖尿病患者动脉粥样硬化血栓形成加速。为了观察2型糖尿病常见的高血糖和高胰岛素血症是否会在体内急性影响血浆纤维蛋白溶解，我们评估了高血糖胰岛素钳夹（n=8）、正常血糖高胰岛素钳夹（n=7）或生理盐水输注（n=15）后大鼠的血浆纤维蛋白溶解（纤维蛋白板溶解、游离PAI-1活性和t-PA活性）。与各自的对照组相比，在高血糖和高胰岛素钳夹后，血浆纤维蛋白溶解活性急剧降低（纤维蛋白板上的平均溶解面积，139 +/- 21 vs. 323 +/- 30 mm） (2)
Decreased plasma fibrinolysis may contribute to accelerated atherothrombosis in diabetes. To observe whether hyperglycemia and hyperinsulinemia, common findings in type 2 diabetes, acutely affect plasma fibrinolysis in vivo, we evaluated plasma fibrinolysis (lysis of fibrin plates, free PAI-1 activity and t-PA activity) in the rat after a hyperglycemic euinsulinemic clamp (n=8), an euglycemic hyperinsulinemic clamp (n=7) or a saline infusion (n=15). Plasma fibrinolytic activity was sharply reduced after both the hyperglycemic and hyperinsulinemic clamps as compared to the respective controls (mean lysis areas on the fibrin plate, 139 +/- 21 vs. 323 +/- 30 mm(2), p