Vascular endothelial function in health and diseases.
Vascular endothelial function in health and diseases.
复制标题
DOI：
10.1016/j.pathophys.2008.02.002
复制
发表时间：
2008-06-01
期刊：
影响因子：
--
通讯作者：
Laher, I
中科院分区：
文献类型：
--
作者：
Khazaei, M;Moien-Afshari, F;Laher, I
血管内皮约占体重（1kg）的1%，表面积约5000m(2)。内皮是一种多功能内分泌器官，位于血管壁和循环血液之间，在血管稳态中发挥着关键作用。内皮细胞既是心血管疾病的靶标，又是心血管疾病的介质。内皮释放多种松弛和收缩因子，可影响血管稳态。内皮功能障碍，无论是由物理损伤还是细胞损伤引起，都会导致改变内皮正常稳态特性的代偿反应。在这篇综述中，我们总结了内皮功能的一些生理方面，然后讨论了一些病理条件下的内皮功能障碍。
The vascular endothelium constitutes approximately 1% of body mass (1kg) and has a surface area of approximately 5000m(2). The endothelium is a multifunctional endocrine organ strategically placed between the vessel wall and the circulating blood, and has a key role in vascular homeostasis. The endothelium is both a target for and mediator of cardiovascular disease. The endothelium releases several relaxing and constricting factors, which can affect vascular homeostasis. Endothelial dysfunction, whether caused by physical injury or cellular damage, leads to compensatory responses that alter the normal homeostatic properties of the endothelium. In this review, we summarized some physiological aspects of endothelial function and then we discussed endothelial dysfunction during some pathological conditions.