Hyperferritinemia after adult allogeneic hematopoietic cell transplantation: quantification of iron burden by determining non-transferrin-bound iron.
Hyperferritinemia after adult allogeneic hematopoietic cell transplantation: quantification of iron burden by determining non-transferrin-bound iron.
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成人同种异体造血细胞移植后的高铁蛋白血症：通过测定非转铁蛋白结合铁来量化铁负荷。
DOI：
10.1007/s12185-012-1252-1
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Koichi Miyam
中科院分区：
文献类型：
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作者：
Tatsunori Goto;Katsuya Ikuta;Yoshihiro Inamoto;Sonoko Kamoshita;Emi Yokohata;Daisuke Koyama;Koichi Onodera;Aika Seto;Keisuke Watanabe;Nobuhiko Imahashi;Shokichi Tsukamoto;Yukiyasu Ozaw;Katsunori Sasaki;Masafumi Ito;Yutaka Kohgo;Koichi Miyam
铁超载是异基因造血细胞移植（HCT）中常见的并发症。我们使用血清铁蛋白研究了122名同种异体HCT存活者的铁过载患病率，这些存活者的中位数为1259天（范围134-4261）。我们还通过测定非转铁蛋白结合铁（NTBI）来定量铁过载，这比铁蛋白更直接地反映了铁过载，并将结果与铁蛋白测定的结果进行了比较。52例患者（43%）表现为高铁蛋白血症（HF）（血清铁蛋白>1000 ng/mL），血清铁蛋白与输血红细胞单位数之间存在中度相关性（ρ = 0.71）。在多变量分析中，HF是肝功能障碍（P= 0.0001）和糖尿病（P= 0.02）的显著风险因素，与体力状态的相关程度较低（P= 0.08）。血清铁蛋白与NTBI之间存在显著相关性（ρ = 0.59）;然而，NTBI与这些结果的相关性弱于血清铁蛋白。总之，血清铁蛋白是同种异体HCT后铁过载的良好替代标志物，并且比NTBI更准确地反映器官损伤。
Iron overload is a common complication in allogeneic hematopoietic cell transplantation (HCT). We studied the prevalence of iron overload using serum ferritin from 122 allogeneic HCT survivors who had survived a median of 1259 (range 134–4261) days. We also quantified iron overload by determining non-transferrin-bound iron (NTBI), which reflects iron overload more directly than ferritin, and compared the results with those of the ferritin assay. Fifty-two patients (43 %) showed hyperferritinemia (HF) (serum ferritin >1000 ng/mL), and there was a moderate correlation between serum ferritin and the number of transfused red blood cell units (ρ = 0.71). In multivariate analyses, HF was a significant risk factor for liver dysfunction (P= 0.0001) and diabetes (P= 0.02), and was related to a lesser extent with performance status (P= 0.08). There was a significant correlation between serum ferritin and NTBI (ρ = 0.59); however, the association of NTBI with these outcomes was weaker than that of serum ferritin. In conclusion, serum ferritin is a good surrogate marker of iron overload after allogeneic HCT, and reflects organ damage more accurately than NTBI.