Potent antimitotic and cell growth inhibitory properties of substituted chalcones
Potent antimitotic and cell growth inhibitory properties of substituted chalcones
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DOI：
10.1016/s0960-894x(98)00162-0
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发表时间：
1998-05-05
影响因子：
2.7
通讯作者：
Rennison, D
中科院分区：
文献类型：
--
作者：
Ducki, S;Forrest, R;Rennison, D
合成了一系列取代的查耳酮，并筛选了针对 K562 人白血病细胞系的细胞毒活性。 (E)-3-(3"-羟基-4"-甲氧基苯基)-2-甲基-1-(3',4',5'-三甲氧基苯基)-prop-2-en-1-one [IC50 (K562) 0.21 nM]被发现是最活跃的。讨论了查尔酮的构象和细胞毒性之间的关系。 (C) 1998 Elsevier Science Ltd. 保留所有权利。
A series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3"-Hydroxy-4"-methoxyphenyl)-2-methyl-1-(3',4',5'-trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.