RELATIONSHIP BETWEEN LOCAL AND TOTAL BONE MASS IN OSTEOPOROSIS
RELATIONSHIP BETWEEN LOCAL AND TOTAL BONE MASS IN OSTEOPOROSIS
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DOI：
10.1016/0026-0495(75)90140-7
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发表时间：
1975-01-01
影响因子：
9.8
通讯作者：
NELP, WB
中科院分区：
文献类型：
--
作者：
MANZKE, E;CHESNUT, CH;NELP, WB
本文研究了不同体型的骨质疏松症患者（女性12例，男性2例）体内总钙（TBC）与局部骨钙量（BCM）的关系。两种方法估计BCM：光子吸收法和射线形态测定法。TBC通过全身中子活化分析估计。由于99%的TBC位于骨骼中，因此假设TBC本质上是骨骼（钙）总质量的度量。TBC为482 ~ 1076 g。在桡骨、尺骨和肱骨六个不同部位的TBC和BCM之间，发现高度相关值为0.84 ~ 0.94,p< 0.001。此外，在桡骨远端十分之一处的BCM与其他五个部位的BCM之间，发现高度相关性为0.89至0.95,p< 0.001。身高和TBC之间也有很高的相关性，但部分相关性表明，TBC和BCM之间的相关性很小。与上述结果相反，x线摄影形态学测定的BCM与TBC之间的相关性较弱或不显著。当TBC和BCM以其平均值的百分比表示时，描述TBC和BCM之间关系的估计方程的斜率基本上是相同的，但明显小于1，这是如果TBC和BCM以相同的相对速率变化所期望的斜率值。从这些关系中，我们得出结论：(1)BCM的变化率在6个检测位点是相似的，(2)这6个位点的变化率相对于全身钙的变化要快得多。BCM率的变化是否与达到最大BCM期间的增加率或随后的BCM损失率有关，或两者都有待确定。
The relationship between total body calcium (TBC) and local bone calcium mass (BCM) was studied in a group of osteoporotic patients (12 females and two males) with a wide range of body size. Two methods were used to estimate BCM: photon absorptiometry and radiographic morphometry. TBC was estimated by total-body neutron-activation analysis. Since 99% of TBC is located in the skeleton, it was assumed that TBC was essentially a measure of total skeletal (calcium) mass. TBC ranged from 482 to 1076 g. High correlations withrvalues from 0.84 to 0.94,p< 0.001, were found between TBC and BCM measured by absorptiometry at six different sites of radius, ulna, and humerus. Additionally, high correlations withrvalues from 0.89 to 0.95,p< 0.001, were found between BCM at the distal tenth of the radius and BCM at the five other sites. A high correlation was also found between body height and TBC, but partial correlations indicated that this accounted for very little of the correlation between TBC and BCM. In contrast to the above, correlations between BCM determined by radiographic morphometry and TBC were weak or nonsignificant. When TBC and BCM were expressed as per cent of their mean value, the slopes of the estimating equations, describing the relationships between TBC and BCM, were essentially the same, but significantly less than one, which is the value of the slope expected if TBC and BCM had changed at the same relative rate. From these relationships, we conclude (1) that the rate of change in BCM was similar in the six sites examined, and (2) that the rate of change in these six sites was relatively more rapid than the change in total body calcium. Whether the change in rate of BCM was related to rate of increase during attainment of maximum BCM or subsequent rate of loss of BCM or both remains to be determined.