Rapid encoding of musical tones discovered in whole-brain connectivity
Rapid encoding of musical tones discovered in whole-brain connectivity
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DOI：
10.1016/j.neuroimage.2021.118735
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发表时间：
2021-11-26
期刊：
影响因子：
5.7
通讯作者：
Kringelbach, M. L.
中科院分区：
文献类型：
--
作者：
Bonetti, L.;Brattico, E.;Kringelbach, M. L.
信息编码已经得到了广泛的神经科学的关注，但潜在的快速时空脑动力学仍然在很大程度上未知。在这里，我们研究了快速的大脑机制编码的声音形成一个复杂的时间序列。具体来说，我们使用脑磁图（MEG）记录了68名参与者在听高度结构化的音乐前奏时的大脑活动。使用相位同步和图形理论的措施进行功能连接分析表明，在编码的声音，包括初级和次级听觉皮层，额盖，海马，基底神经节招募的大脑区域的大网络。此外，我们的研究结果强调了大脑活动从初级听觉皮层到更高阶的关联区域，包括全脑网络中的颞极和上级颞极的快速过渡，发生在编码过程的前220 ms。此外，我们发现，个体差异沿着认知能力和音乐才能调制的程度，在编码过程中涉及的大脑区域的中心。事实上，具有更高音乐专长的参与者表现出更强的上级颞回和颞叶的中心性，而具有高工作记忆能力的个体则表现出更强的额盖中心性。总之，我们的研究揭示了负责声音编码及其与个体差异关系的大脑网络动态的快速展开，显示了一幅复杂的画面，超出了众所周知的听觉区域的参与。事实上，我们的研究结果扩展了我们对人类大脑中听觉模式编码的一般机制的理解。
Information encoding has received a wide neuroscientific attention, but the underlying rapid spatiotemporal brain dynamics remain largely unknown. Here, we investigated the rapid brain mechanisms for encoding of sounds forming a complex temporal sequence. Specifically, we used magnetoencephalography (MEG) to record the brain activity of 68 participants while they listened to a highly structured musical prelude. Functional connectivity analyses performed using phase synchronisation and graph theoretical measures showed a large network of brain areas recruited during encoding of sounds, comprising primary and secondary auditory cortices, frontal operculum, insula, hippocampus and basal ganglia. Moreover, our results highlighted the rapid transition of brain activity from primary auditory cortex to higher order association areas including insula and superior temporal pole within a whole-brain network, occurring during the first 220 ms of the encoding process. Further, we discovered that individual differences along cognitive abilities and musicianship modulated the degree centrality of the brain areas implicated in the encoding process. Indeed, participants with higher musical expertise presented a stronger centrality of superior temporal gyrus and insula, while individuals with high working memory abilities showed a stronger centrality of frontal operculum. In conclusion, our study revealed the rapid unfolding of brain network dynamics responsible for the encoding of sounds and their relationship with individual differences, showing a complex picture which extends beyond the well-known involvement of auditory areas. Indeed, our results expanded our understanding of the general mechanisms underlying auditory pattern encoding in the human brain.