Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome
Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome
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DOI：
10.3390/medsci7080086
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发表时间：
2019-08
期刊：
影响因子：
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通讯作者：
E. Stener-Victorin;M. Manti;R. Fornes;Sanjiv Risal;Haojiang Lu;A. Benrick
中科院分区：
文献类型：
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作者：
E. Stener-Victorin;M. Manti;R. Fornes;Sanjiv Risal;Haojiang Lu;A. Benrick
患有多囊卵巢综合征(PCOS)的女性表现出精神健康受损。与肥胖无关，患有多囊卵巢综合征的女性更容易被诊断为焦虑和抑郁以及其他神经精神疾病。在怀孕期间，患有多囊卵巢综合征的妇女表现出高循环雄激素水平，这可能导致产前雄激素暴露，影响发育中的胎儿，并增加后代情绪障碍的风险。越来越多的证据支持非遗传的母体因素在下一代多囊卵巢综合征和焦虑症的发展中的作用。反映子代多囊卵巢综合征焦虑表型的产前雄性激素化啮齿动物模型发现，有证据表明杏仁核中的胎盘和雄激素受体功能发生了变化，以及与情绪调节和类固醇受体相关的基因在杏仁核和海马区的表达发生了变化。这些发现定义了一种以前未知的机制，这可能对于理解母亲雄激素过剩如何增加女儿以及部分PCOS母亲的儿子患焦虑症的风险至关重要。母亲肥胖是多囊卵巢综合征的另一个常见特征，导致不利的宫内环境，这可能会导致后代的精神问题。将讨论环境因素，如产前雄激素暴露和肥胖是否会增加后代患精神疾病的易感性。
Women with polycystic ovary syndrome (PCOS) exhibit compromised psychiatric health. Independent of obesity, women with PCOS are more susceptible to have anxiety and depression diagnoses and other neuropsychiatric disorders. During pregnancy women with PCOS display high circulating androgen levels that may cause prenatal androgen exposure affecting the growing fetus and increasing the risk of mood disorders in offspring. Increasing evidence supports a non-genetic, maternal contribution to the development of PCOS and anxiety disorders in the next generation. Prenatal androgenized rodent models reflecting the anxiety-like phenotype of PCOS in the offspring, found evidence for the altered placenta and androgen receptor function in the amygdala, together with changes in the expression of genes associated with emotional regulation and steroid receptors in the amygdala and hippocampus. These findings defined a previously unknown mechanism that may be critical in understanding how maternal androgen excess can increase the risk of developing anxiety disorders in daughters and partly in sons of PCOS mothers. Maternal obesity is another common feature of PCOS causing an unfavorable intrauterine environment which may contribute to psychiatric problems in the offspring. Whether environmental factors such as prenatal androgen exposure and obesity increase the offspring’s susceptibility to develop psychiatric ill-health will be discussed.