The inhibitory effect of kampou extracts on in vitro calcium oxalate crystallization and in vivo stone formation in an animal model.
The inhibitory effect of kampou extracts on in vitro calcium oxalate crystallization and in vivo stone formation in an animal model.
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DOI：
10.1111/j.1442-2042.1995.tb00429.x
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发表时间：
1995-05-01
期刊：
影响因子：
--
通讯作者：
Sugiyama, K
中科院分区：
文献类型：
--
作者：
Koide, T;Yamaguchi, S;Sugiyama, K
贡布医学是日本传统的治疗体系，起源于中国，几百年来一直被用来治疗各种疾病，直到被西医取代。近年来，许多医生重新燃起了对坎普医学的兴趣。然而，不幸的是，到目前为止，几乎没有使用客观的科学方法进行评估，坎布族药物的药效学仍然不清楚。总体而言，根据长期使用的经验，坎普药的副作用比西药少。我们首先选择了16种甘布提取物，在体外筛选出可能的草酸钙结石预防药物。因此，选择了两种坎普提取物，Takusya和Kagosou，作为潜在的坎布提取物，用于预防结石。接下来，这两种甘布提取物在动物模型上进行了体内测试，以确定它们对结石形成的影响。Takusya显示出显著的结石预防作用，而Kagosou则没有。最后，含有Takusya的Chorei-to已被批准作为日本尿路结石患者的处方药，在两种不同浓度下进行了体内试验。结果是，低剂量的Chorei--相当于人类每天每单位体重的剂量--显示出明显的结石预防作用，尽管这会减少柠檬酸盐的排泄。相比之下，高剂量的Chorei-to在体内并没有显示出预防结石的作用。
Kampou medicine is a traditional Japanese therapeutic system which originated in China and was used to treat various diseases for hundreds of years until it was superseded by Western medicine. In recent years, there has been a resurgence of interest in Kampou medicine among many physicians. Unfortunately, however, little evaluation has been performed using objective scientific methods until now, and the pharmacodynamics of Kampou medicine are still unclear. Generally speaking, Kampou medicine has been shown to have fewer side-effects than Western medicine based on the experience gained from its long usage. We first selected 16 Kampou extracts for screening as possible calcium oxalate stone prophylactic agents in vitro. This resulted in the selection of two kinds of Kampou extracts, Takusya and Kagosou, as potential Kampou extracts for stone prophylaxis. Next, these two Kampou extracts were tested in vivo for their effects on stone formation in an animal model. Takusya showed significant stone prophylaxis, while Kagosou did not. Lastly, Chorei-to, which contains Takusya and has been approved for prescription as a Kampou medicine for urolithiasis patients in Japan, was examined in vivo at two different concentrations. As a result, a low dose of Chorei-to which corresponded to the human daily dose per unit of body weight exhibited apparent stone prophylaxis, despite the disadvantage of decreasing citrate excretion. In contrast, high doses of Chorei-to did not exhibit stone prophylaxis in vivo.(ABSTRACT TRUNCATED AT 250 WORDS)