Transmural cellular heterogeneity in myocardial electromechanics
Transmural cellular heterogeneity in myocardial electromechanics
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DOI：
10.1007/s12576-017-0541-0
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发表时间：
2018-07-01
影响因子：
2.3
通讯作者：
Solovyova, Olga
中科院分区：
文献类型：
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作者：
Khokhlova, Anastasia;Balakina-Vikulova, Nathalie;Solovyova, Olga
心肌异质性是正常心脏的一个属性。我们开发了心内膜下 (ENDO) 和心外膜下 (EPI) 心室区域心肌细胞的综合模型，该模型考虑了豚鼠心脏细胞内机电耦合特定区域特征的实验数据。该模型充分模拟了 ENDO 和 EPI 细胞之间动作电位和收缩差异的实验数据。建模结果预测，分离的 ENDO 和 EPI 心肌细胞中钙处理和肌丝力学参数的异质性对于通过机械-钙-电反馈的协作机制产生 Ca2+ 瞬变和收缩曲线的差异至关重要，并且可能进一步轻微调节细胞之间电特性的跨壁差异。仿真结果预测 ENDO 细胞比 EPI 细胞对机械负载变化具有更高的敏感性。这些数据对于了解完整心脏中心肌细胞的行为非常重要。
Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the differences in the action potential and contraction between the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes are essential to produce the differences in Ca2+ transients and contraction profiles via cooperative mechanisms of mechano-calcium-electric feedback and may further slightly modulate transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in the mechanical load than EPI cells. These data are important for understanding the behavior of cardiomyocytes in the intact heart.