Human chorionic gonadotropin radioantibodies in the radioimmunodetection of cancer and for disclosure of occult metastases.
Human chorionic gonadotropin radioantibodies in the radioimmunodetection of cancer and for disclosure of occult metastases.
复制标题
人绒毛膜促性腺激素放射性抗体在癌症放射免疫检测和揭示隐匿性转移中的应用。
DOI：
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发表时间：
1981
影响因子：
11.1
通讯作者：
F. Deland
中科院分区：
文献类型：
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作者：
D. Goldenberg;E. Kim;F. Deland
通过注射131 I标记的抗人绒毛膜促性腺激素（hCG;绒毛膜促性腺激素）山羊抗体IgG，并在24小时和48小时后使用γ闪烁相机进行全身光扫描，对25名患者进行了含人绒毛膜促性腺激素（hCG;绒毛膜促性腺激素）的肿瘤的放射免疫检测（RaID）。所有10例经证实肿瘤部位的睾丸癌患者的RaID结果均为阳性，而3例无已知肿瘤的患者则为阴性。4例葡萄胎患者和1例退化性妊娠产物患者的RaID结果阳性，与血清hCG滴度升高一致。在肺癌或卵巢癌患者中获得了两个假阳性结果，而观察到肺癌患者肝转移和血清hCG滴度升高的假阴性结果。在10名睾丸癌患者中，RaID发现的14个肿瘤部位中，有4个是在使用任何其他检测方法之前通过RaID发现的，并通过其他措施提供了几天到1年以上的明确诊断的提前时间。尽管部分患者血清hCG水平较高，甚至超过3 μ g/ml，但异种抗体仍能定位于肿瘤内。在研究的任何患者中均未观察到不良反应。因此，hCG RaID似乎是一种安全有效的检测和定位hCG产生肿瘤的方法，并已被发现可以发现隐匿性睾丸癌。
Radioimmunodetection (RaID) of tumors containing human chorionic gonadotropin (hCG; choriogonadotropin) was evaluated in 25 patients by injecting 131I-labeled goat antibody IgG against hCG and performing total-body photoscans with a gamma scintillation camera 24 and 48 hr later. All 10 testicular cancer patients with proven tumor sites had positive RaID results, whereas three cases without known tumor were negative. Four patients with hydatidiform mole and one with degenerative products of conception showed positive RaID results consistent with elevated serum hCG titers. Two putatively false-positive results were obtained in patients with lung or ovarian cancer, whereas a false-negative metastasis to the liver of a patient with lung cancer and an elevated serum hCG titer was observed. Of 14 tumor sites found by RaID in 10 testicular cancer patients, 4 were revealed by RaID prior to any other detection method used and provided a lead time to definitive diagnosis by other measures of a few days to greater than 1 yr. Although a number of patients had high serum hCG levels, even exceeding 3 microgram/ml, the xenogeneic antibody was capable of localizing in tumor. No adverse effects were noted in any of the patients studied. Thus, hCG RaID appears to be a safe and effective method of detecting and locating hCG-producing tumors and has been found to disclose occult testicular cancers.