Assessment of CD10 in the diagnosis of small B-cell lymphomas: a multiparameter flow cytometric study.
Assessment of CD10 in the diagnosis of small B-cell lymphomas: a multiparameter flow cytometric study.
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CD10 在小 B 细胞淋巴瘤诊断中的评估：多参数流式细胞术研究。
DOI：
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发表时间：
2002
影响因子：
3.5
通讯作者：
S. Kroft
中科院分区：
文献类型：
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作者：
Yin Xu;R. Mckenna;S. Kroft
我们评估了多参数流式细胞术与聚类分析在诊断一系列100例特征明确的小B细胞淋巴瘤（SBCL）中的有用性。100例中，滤泡性淋巴瘤（FL）58例，边缘区淋巴瘤（MZL）17例，小淋巴细胞性淋巴瘤15例，套细胞淋巴瘤（MCL）10例。在58例FL中，57例为CD 10阳性（98%灵敏度）。1例阴性病例不寻常，因为其发生在小肠。然;在42例其他SBCL中，2例为CD 10+（95%特异性），1例为CD 5 +/cyclin D1 + MCL，另1例为结节性MZL。我们发现，使用多参数流式细胞术与聚类分析的CD 10表达的评估是高度敏感性和特异性的FL的诊断，验证其有用的情况下，足够的组织是没有明确的组织学诊断。
We evaluated the usefulness of multiparameter flow cytometry with cluster analysis in the diagnosis of a series of 100 well-characterized small B-cell lymphomas (SBCLs). The histologic diagnoses in the 100 cases were follicular lymphoma (FL) in 58, marginal zone lymphoma (MZL) in 17, small lymphocytic lymphoma in 15, and mantle cell lymphoma (MCL) in 10. Of the 58 FLs, 57 were CD10 positive (98% sensitivity). The 1 negative case was unusual in that it occurred in the small intestine. However; architectural, cytologic, and immunohistochemicalfeatures were diagnostic of FL. Of 42 other SBCLs, 2 were CD10+ (95% specificity); 1 was a CD5+/cyclin D1 + MCL, and the other was an extranodal MZL. We found that assessment of CD10 expression using multiparameter flow cytometry with cluster analysis is highly sensitive and specific for the diagnosis of FL, validating its usefulness in situations in which adequate tissue is not available for definitive histologic diagnosis.
使用单克隆抗体对两种生发中心类型（中心母细胞/中心细胞和中心细胞）恶性淋巴瘤进行免疫组织学表征。
DOI：
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发表时间：
1984
期刊：
The American journal of pathology
影响因子：
--
作者：
Harris,NL;Nadler,LM;Bhan,AK
通讯作者：
Bhan,AK
III 级和滤泡性淋巴瘤的滤泡间浸润中 CD10 表达降低。
DOI：
10.1309/b6mk-j7nf-a6jp-x56k
发表时间：
2001
期刊：
American journal of clinical pathology.
影响因子：
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作者：
Eshoa,C;Perkins,S;Kampalath,B;Shidham,V;Juckett,M;Chang,CC
通讯作者：
Chang,CC