Radiofrequency ablation vs. microwave ablation for patients with benign thyroid nodules: a propensity score matching study
Radiofrequency ablation vs. microwave ablation for patients with benign thyroid nodules: a propensity score matching study
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良性甲状腺结节患者的射频消融与微波消融：倾向评分匹配研究
DOI：
10.1007/s12020-016-1173-5
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发表时间：
2017-02-01
期刊：
影响因子：
3.7
通讯作者：
Xu, Hui-Xiong
中科院分区：
文献类型：
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作者：
Yue, Wen-Wen;Wang, Shu-Rong;Xu, Hui-Xiong
目的比较射频消融术和微波消融术治疗甲状腺良性结节的疗效和安全性。方法对260例甲状腺良性结节患者进行回顾性研究，其中射频消融术102例，微波消融术158例。为了减少由于回溯性分配而产生的混淆偏差，采用倾向性评分匹配来平衡两组的消融前数据。配对后，共创建102对患者配对(1：1)。治疗后1、3、6、12个月比较两组的体积缩小率、治疗成功率、症状和美容评分及主要并发症。结果两组6个月时结节体积缩小率：79.4vs.77.2 %，P= 0.108；症状评分：2.1vs.1.9，P= 0.456；美容评分：2.1vs.2.3，P= 0.119；治疗成功率：99vs.97 %，P= 0.621)和12个月(体积缩小率：83.6vs.81.6 %，P= 0.144；症状评分：1.5vs.1.5，P= 0.869；美容评分：1.6vs.1.7，P= 0.409；治疗成功率：100vs.100 %，P>； 0.99)。两组均未发生重大并发症(P>； =0.99)。结论两种术式在减容效果、治疗成功率、症状及美容评分、治疗相关并发症等方面差异无统计学意义。射频消融术和微波消融术是治疗甲状腺良性结节安全有效的方法。
PurposeTo compare the efficacy and the safety of radiofrequency ablation and microwave ablation for treatment of benign thyroid nodules using a propensity score matching study design.MethodsTwo hundred and sixty patients with benign thyroid nodules were studied retrospectively, including 102 patients treated with radiofrequency ablation and 158 treated with microwave ablation. To reduce confounding bias due to retrospective assignment, propensity score matching was performed to balance the preablation data of the two groups. After matching, a total of 102 patient pairs (1:1) were created. The volume reduction ratio, therapeutic success rate, symptom and cosmetic score, and major complication were compared between the two groups at 1, 3, 6, and 12 months after treatment.ResultsBetween the well-matched groups, no significant differences were found in all nodule volume-related end points at 6 months (volume reduction ratio: 79.4 vs. 77.2 %,P= 0.108; symptom score: 2.1 vs. 1.9,P= 0.456; cosmetic score: 2.1 vs. 2.3,P= 0.119; therapeutic success rate: 99 vs. 97 %,P= 0.621) and 12 months (volume reduction ratio: 83.6 vs. 81.6 %,P= 0.144; symptom score: 1.5 vs. 1.5,P= 0.869; cosmetic score: 1.6 vs. 1.7,P= 0.409; therapeutic success rate: 100 vs. 100 %,P> 0.99) after treatment. No major complications occurred in either group (P> 0.99).ConclusionsWith well-matched groups and consistent procedure design, our results demonstrated that the volume reduction ratio, therapeutic success rate, symptom and cosmetic score, and complications related to treatment for the two techniques are equivalent. Radiofrequency ablation and microwave ablation are both effective and safe methods in treating benign thyroid nodules.