Preoperative Neutrophil-to-Lymphocyte Ratio (NLR) is Associated with Reduced Disease-free Survival Following Curative Resection of Pancreatic Adenocarcinoma
Preoperative Neutrophil-to-Lymphocyte Ratio (NLR) is Associated with Reduced Disease-free Survival Following Curative Resection of Pancreatic Adenocarcinoma
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DOI：
10.1007/s00268-011-0984-z
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发表时间：
2011-04-01
影响因子：
2.6
通讯作者：
Berry, D. P.
中科院分区：
文献类型：
--
作者：
Garcea, G.;Ladwa, N.;Berry, D. P.
背景血清学促炎标志物，如 C 反应蛋白 (CRP)、中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 与许多不同类型癌症的生存率降低有关。本研究确定了这些标志物的术前价值对于可切除的胰腺腺癌患者的预后价值。方法将2001年至今连续接受胰十二指肠切除术的胰腺导管腺癌患者纳入我们的数据库。记录就诊时的 CRP、NLR 和 PLR 以及总体生存率和无病生存率。结果 确定了 74 名患者。总体中位生存期为 35.0 个月，中位无病生存期为 27.0 个月。随访时间为 1 至 125.8 个月。在随访期间出现复发的患者中，术前 NLR 显着更高（4.5 比 3.1）。两组之间的 CRP 和 PLR 没有发现显着差异。 Kaplan-Meier 生存分析显示，NLR > 5 患者的无病生存期为 12 个月，而 NLR > 5 患者的无病生存期为 52 个月 (p < 0.001)。结论 术前 NLR 提供了有关胰腺导管腺癌治愈性切除术后无病生存期的重要预后信息。
Background Serological proinflammatory markers such as C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been associated with reduced survival for many different types of cancer. This study determined the prognostic value of the preoperative value of these markers in patients with resectable pancreatic adenocarcinoma.Methods Consecutive patients who underwent pancreaticoduodenectomy for pancreatic ductal adenocarcinoma were entered into our database from 2001 to the present day. CRP, NLR, and PLR at the time of presentation were recorded as well as overall and disease-free survival.Results Seventy-four patients were identified. Overall median survival was 35.0 months and median disease-free survival was 27.0 months. Follow-up ranged from 1 to 125.8 months. Preoperative NLR was significantly greater in those patients who developed recurrence in the follow-up period (4.5 vs. 3.1). CRP and PLR were not found to differ significantly between the two groups. Kaplan-Meier survival analysis of patients with NLR > 5 demonstrated a disease-free survival of 12 months compared with 52 months for those patients with NLR > 5 (p < 0.001).Conclusion Preoperative NLR offers important prognostic information regarding disease-free survival following curative resection of pancreatic ductal adenocarcinoma.