Polycation cytotoxicity: a delicate matter for nucleic acid therapy-focus on polyethylenimine
Polycation cytotoxicity: a delicate matter for nucleic acid therapy-focus on polyethylenimine
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DOI：
10.1039/c000190b
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发表时间：
2010-01-01
期刊：
影响因子：
3.4
通讯作者：
Moghimi, S. Moein
中科院分区：
文献类型：
--
作者：
Parhamifar, Ladan;Larsen, Anna K.;Moghimi, S. Moein
这篇文章提供了一个关键的评估核酸治疗所面临的主要挑战，专注于安全性和有效性的交付策略，使用合成聚阳离子，特别是聚乙烯亚胺。确定了该领域的缺陷和进一步研究的途径，这可能有助于设计和选择用于临床基因治疗和RNA干扰递送的更安全的聚阳离子载体的扩展和改进的文库。
This article provides a critical assessment of the major challenges facing nucleic acid therapeutics, focusing on the safety and efficacy of delivery strategies using synthetic polycations and particularly polyethylenimines. Deficiencies in the field and avenues for further research are identified that could help with design and selection of an expanded and improved library of safer polycationic vectors for clinical gene therapy and RNA interference delivery.