The Vitamin D Endocrine System and Its Therapeutic Potential

The Vitamin D Endocrine System and Its Therapeutic Potential
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维生素 D 内分泌系统及其治疗潜力

DOI:
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发表时间:
1996
期刊:
影响因子:
--
通讯作者:
H. DeLuca
H. DeLuca
中科院分区:
--
文献类型:
--
作者:
R. Ettinger;H. DeLuca

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本章致力于描述维生素D内分泌系统,维生素D的活性激素形式如何起作用,以及治疗各种疾病的潜力,从代谢性骨病到牛皮癣和癌症等各种疾病。随着维生素D分子活化的发现,维生素D的代谢物及其类似物在人类疾病中的应用也越来越广泛。组织中维生素D受体的发现导致了维生素D的新功能的发现,因为它参与单核细胞从早幼粒细胞的分化和发育。进一步详细分析1,25-二羟基维生素d3在启动靶基因转录中的作用将产生新的信息,这些信息不仅对理解这些复杂的系统有价值,而且对最大限度地治疗疾病提供指导。
Publisher Summary This chapter is devoted to describing the vitamin D endocrine system, how the active hormonal form of vitamin D works, and the potential for treatment of a variety of diseases, ranging from metabolic bone diseases to such diverse disorders as psoriasis and cancer. With the discovery of the activation of the vitamin D molecule has come the application of the metabolites of vitamin D and its analogues to human disease. The discovery of the vitamin D receptor in tissues has resulted in the discovery of new functions of vitamin D, as its involvement in the differentiation and development of the monocyte from the promyelocyte. A further detailed analysis of the role of 1,25-Dihydroxyvitamin D 3 in initiating transcription of target genes will yield new information that will be of value not only in understanding these complex systems but in providing guidance to maximize treatment of disease.
体内 1,25-二羟基维生素 D3 合成位点的研究。
DOI: --
发表时间: 1983
期刊: The Journal of biological chemistry
影响因子: --
作者:
Reeve,L;Tanaka,Y;DeLuca,HF
通讯作者: DeLuca,HF
DOI: --
发表时间: 1988
影响因子: 4.2
作者:
道脇幸博
通讯作者: 道脇幸博
24-同源 1,25-二羟基维生素 D3 化合物:钙分离和细胞分化活性。
DOI: 10.1021/bi00453a026
发表时间: 1990
期刊: Biochemistry
影响因子: 2.9
作者:
Perlman,K;Kutner,A;Prahl,J;Smith,C;Inaba,M;Schnoes,HK;DeLuca,HF
通讯作者: DeLuca,HF
DOI: 10.1016/s0190-9622(88)70207-8
发表时间: 1988
影响因子: 13.8
作者:
Smith,EL;Pincus,SH;Donovan,L;Holick,MF
通讯作者: Holick,MF
禽肾线粒体血红素蛋白 P-4501 α:分离、表征和 NADPH-铁氧还蛋白还原酶依赖性活性。
DOI: 10.1016/0304-4165(90)90044-w
发表时间: 1990
期刊: Biochimica et biophysica acta
影响因子: --
作者:
Mandel,ML;Swartz,SJ;Ghazarian,JG
通讯作者: Ghazarian,JG