Cellular Configuration of Single Octopamine Neurons in Drosophila
Cellular Configuration of Single Octopamine Neurons in Drosophila
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DOI：
10.1002/cne.22337
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发表时间：
2010-06-15
影响因子：
2.5
通讯作者：
Tanimoto, Hiromu
中科院分区：
文献类型：
--
作者：
Busch, Sebastian;Tanimoto, Hiromu
昆虫中枢神经系统中单个章鱼胺中位神经元为单个鉴定细胞的比较神经解剖学提供了一个很好的模型系统。食道下神经节的中位章鱼胺簇由确定的成对和未成对的中间神经元组成，它们为大脑和食道下神经节提供广泛的分支。复杂细胞网络背后的发育程序尚不清楚。在这里，我们绘制了果蝇食道下神经节中单个章鱼胺神经元的节段位置和发育起源。我们证明了位于下颌骨和上颌节段的两组未配对的中间神经元在大脑中表现出相同的投影模式。此外，我们发现成对和未成对的神经元属于不同的谱系。中位神经元的物种间比较表明，不同物种的许多章鱼胺神经元投射到相同的目标区域。这种形态相似的神经元可以来自不同物种的不同谱系（即成对和非成对神经元）。[j] .中国生物医学工程学报，2016,18(5):555 - 564。(C) 2010 Wiley-Liss, Inc。
Individual median octopamine neurons in the insect central nervous system serve as an excellent model system for comparative neuroanatomy of single identified cells. The median octopamine cluster of the subesophageal ganglion consists of defined sets of paired and unpaired interneurons, which supply the brain and subesophageal ganglion with extensive ramifications. The developmental program underlying the complex cellular network is unknown. Here we map the segmental location and developmental origins of individual octopamine neurons in the Drosophila subesophageal ganglion. We demonstrate that two sets of unpaired median neurons, located in the mandibular and maxillary segments, exhibit the same projection patterns in the brain. Furthermore, we show that the paired and unpaired neurons belong to distinct lineages. Interspecies comparison of median neurons revealed that many individual octopamine neurons in different species project to equivalent target regions. Such identified neurons with similar morphology can derive from distinct lineages in different species (i.e., paired and unpaired neurons). J. Comp. Neurol. 518:2355-2364, 2010. (C) 2010 Wiley-Liss, Inc.