Density and morphology of dendritic spines in mouse neocortex
Density and morphology of dendritic spines in mouse neocortex
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DOI：
10.1016/j.neuroscience.2005.11.038
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发表时间：
2006-01-01
期刊：
影响因子：
3.3
通讯作者：
DeFelipe, J
中科院分区：
文献类型：
--
作者：
Ballesteros-Yáñez, I;Benavides-Piccione, R;DeFelipe, J
锥体细胞的树突棘是皮质兴奋性突触的主要突触后靶点，因此，它们在神经元可塑性和锥体神经元兴奋性输入的整合中都是基础。树突棘的数量和密度在不同种属和不同皮质区的锥体细胞中存在显著差异，灵长类动物中更是如此。这种变化被认为有助于皮质区之间的功能差异。在这项研究中，我们分析了小鼠大脑皮层运动区、体感区和视颞区的树突棘密度。在第三层锥体神经元的基底树突上绘制了超过17，000个个体棘，并在这些皮质区域之间比较了它们的形态。与先前在灵长类动物中的观察相反，小鼠神经元树突上沿着的棘密度没有显著差异。然而，脊柱尺寸（脊柱头部大小和脊柱颈部长度）的系统差异被检测到，其中最大的脊柱被发现在运动区，其次是在躯体感觉区和视觉颞区。(c)2005年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Dendritic spines of pyramidal cells are the main postsynaptic targets of cortical excitatory synapses and as such, they are fundamental both in neuronal plasticity and for the integration of excitatory inputs to pyramidal neurons. There is significant variation in the number and density of dendritic spines among pyramidal cells located in different cortical areas and species, especially in primates. This variation is believed to contribute to functional differences reported among cortical areas. In this study, we analyzed the density of dendritic spines in the motor, somatosensory and visuo-temporal regions of the mouse cerebral cortex. Over 17,000 individual spines on the basal dendrites of layer III pyramidal neurons were drawn and their morphologies compared among these cortical regions. In contrast to previous observations in primates, there was no significant difference in the density of spines along the dendrites of neurons in the mouse. However, systematic differences in spine dimensions (spine head size and spine neck length) were detected, whereby the largest spines were found in the motor region, followed by those in the somatosensory region and those in visuo-temporal region. (c) 2005 IBRO. Published by Elsevier Ltd. All rights reserved.