Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response.
Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response.
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DOI：
10.1074/jbc.r116.714980
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发表时间：
2016-04-08
期刊：
影响因子：
--
通讯作者：
Thorner J
中科院分区：
文献类型：
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作者：
Alvaro CG;Thorner J
1985年分离出了酿酒酵母酿酒酵母的肽交配信息素的DNA，并在1985年分离出来，并且是在任何生物体中都被克隆的动力蛋白G蛋白偶联受体（GPCR）的第一个基因。如今，如今，如本回顾性概述所述，该酵母菌及其受体继续提供了用于研究GPCR发起的信号传导及其调控的途径实验范式。
The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeast Saccharomyces cerevisiae were isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview.