The applications of PET in clinical oncology.
The applications of PET in clinical oncology.
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发表时间：
1991-04
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通讯作者：
L. Strauss;P. Conti
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作者：
L. Strauss;P. Conti
随着将全身PET引入临床环境的新一代PET扫描仪的出现，现在人们对开发用于评估颅内和躯体癌症的方案更感兴趣。PET在临床肿瘤学中的价值已经在各种癌症的研究中得到证实，包括结直肠癌、肺癌、头颈部肿瘤、原发和转移性脑肿瘤、乳腺癌、淋巴瘤、黑色素瘤、骨癌和其他软组织癌症。总结目前PET在肿瘤学中的临床应用，特别关注结直肠癌、肺癌和颅内肿瘤，因为大多数临床试验都集中在这些肿瘤上。描述了目前包括在临床肿瘤成像方案中的各种放射性药物，包括代谢底物，如氟-18-氟脱氧葡萄糖和碳-11-蛋氨酸，以及类似的化疗药物，如氟-18-氟尿嘧啶和氟雌二醇。还试图包括对治疗干预有反应的临床试验的例子。越来越多的肿瘤学PET研究反映了人们对肿瘤学功能成像的日益浓厚的兴趣。
With the advent of a new generation of PET scanners that have introduced whole-body PET to the clinical setting, there is now more interest in developing protocols for the evaluation of both intracranial and somatic cancers. The value of PET in clinical oncology has been demonstrated with studies in a variety of cancers including colorectal carcinomas, lung tumors, head and neck tumors, primary and metastatic brain tumors, breast carcinoma, lymphoma, melanoma, bone cancers, and other soft-tissue cancers. A summary of current clinical applications of PET in oncology is presented with special attention to colorectal, lung, and intracranial neoplasms since the majority of clinical trials have focused on these cancers. A variety of radiopharmaceuticals are described that are currently included in clinical tumor-imaging protocols, including metabolic substrates such as fluorine-18-fluorodeoxyglucose and carbon-11-methionine, and analogs of chemotherapeutic agents such as fluorine-18-fluorouracil and fluoroestradiol. An attempt is also made to include examples of clinical trials that demonstrate response to therapeutic intervention. The increasing number of oncologic PET studies reflects the growing interest in functional imaging in oncology.