Contact dermatitis to garlic; crossreactivity between garlic, onion and tulip
Contact dermatitis to garlic; crossreactivity between garlic, onion and tulip
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大蒜接触性皮炎；
DOI：
10.1007/bf00595924
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
J. Nater
中科院分区：
文献类型：
--
作者：
E. Bleumink;J. Nater
最近我们报道了一例因大蒜而引起的接触性皮炎。这个案例促使我们将大蒜提取物纳入常规斑贴测试系列中。对63名股溃疡患者和168名接触性皮炎患者进行了大蒜水提取物和乙醇提取物的检测，其中6%（主要是40岁以上的女性）出现阳性反应。洋葱提取物没有引起阳性检测，并且大蒜和洋葱之间没有观察到交叉反应。在大蒜检测呈阳性的患者中，只有八分之一的郁金香提取物引起了明显的皮肤反应。发现活性成分对热和酸处理敏感。气相色谱分析表明大蒜提取物中存在郁金香苷-B。郁金香苷-A（郁金香球茎的致敏成分）无法得到证实。郁金香苷（A 和 B）很可能与大蒜提取物刺激表皮后观察到的皮肤反应无关。
Recently we reported a case of contact dermatitis to garlic. This case lead us to include garlic extracts in the routine patch test series. Tests with aqueous and ethanol extracts of garlic were performed in 63 patients with ulcera cruris and in 168 persons with contact dermatitis.In 6% of them, mostly in women over 40 years old, positive reactions were observed. Onion extracts did not give rise to positive tests, and no crossreactivity could be observed between garlic and onion. In only 1 out of 8 patients with positive tests to garlic a tulip extract elicited visible skin responses.The active component was found susceptible to heat, and to acid treatment.Gaschromatographic analyses indicated the presence in garlic extracts of tuliposide-B. Tuliposide-A (the allergenic component of tulip bulbs) could not be demonstrated. Tuliposides (A and B) are to all probability not responsible for the skin responses observed after epicutaneous challenge with garlic extracts.