COMPARISON OF RELATIVE RISKS OBTAINED IN ECOLOGICAL AND INDIVIDUAL STUDIES - SOME METHODOLOGICAL CONSIDERATIONS
COMPARISON OF RELATIVE RISKS OBTAINED IN ECOLOGICAL AND INDIVIDUAL STUDIES - SOME METHODOLOGICAL CONSIDERATIONS
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DOI：
10.1093/ije/16.1.111
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发表时间：
1987-03-01
影响因子：
7.7
通讯作者：
HEMON, D
中科院分区：
文献类型：
--
作者：
RICHARDSON, S;STUCKER, I;HEMON, D
本文涉及生态相关研究中估计相对风险的问题。在第一部分中，讨论了分析汇总数据时遇到的一些偏差，特别关注从汇总和非汇总数据获得的剂量反应关系的形状、外推的必要性以及汇总的规模。在第二部分中，通过四个有关吸烟与不同病理之间的相对风险的例子对这些观点进行了一些实证观察。对来自法国地理数据和病例对照或队列研究的相对风险估计进行了比较。生态研究的表现从考虑的风险因素的强度、混杂因素的地理分布以及不同模型的调整等方面进行了讨论。
This paper is concerned with the problem of estimating relative risks from ecological correlation studies. In the first part, some of the biases encountered when analysing aggregated data are discussed and in particular attention is focused on the shape of the dose-response relationship obtained from aggregated and non-aggregated data, on the need for extrapolation and on the scale of aggregation. In the second part some empirical observations are made on these points by means of four examples concerning the relative risk between smoking and different pathologies. The estimates of relative risks derived from French geographical data and from case control or cohort studies are compared. The performance of ecological studies is discussed with respect to the strength of the risk factor considered, the geographical distribution of confounding factors and the adjustment of different models.