APOLIPOPROTEIN-E GENOTYPE, ALZHEIMERS PATHOLOGIES AND RELATED GENE-EXPRESSION IN THE AGED POPULATION
APOLIPOPROTEIN-E GENOTYPE, ALZHEIMERS PATHOLOGIES AND RELATED GENE-EXPRESSION IN THE AGED POPULATION
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DOI：
10.1016/0169-328x(94)00233-5
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发表时间：
1995-03-01
期刊：
影响因子：
--
通讯作者：
IHARA, Y
中科院分区：
文献类型：
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作者：
OYAMA, F;SHIMADA, H;IHARA, Y
我们从连续尸检获得的38例老年人脑标本中，研究了载脂蛋白E(ApoE)基因分型对阿尔茨海默病(AD)病理及其相关基因表达的影响。APOE2/3、-3/3、-3/4和-4/4型在老年脑组织中均有分布，以ApoE3/3居多。在APOE2/3脑中未检测到AD病理改变，但在其他ApoE组中可见AD病理改变。在ApoE3/3脑中，分别有55%、34%和24%的皮质切片显示老年斑(SPS)、神经原纤维缠结(NFTs)和脑淀粉样血管病(CAA)。在ApoE4/4脑中，SP的形成明显较高。ApoE基因既不影响ApoE、APP或tau基因的表达水平，也不影响后两者的差异表达。这些结果表明，ApoE4/4促进了老年脑AD病理的发展，而ApoE2/3则减缓了AD的发展，但这并不是通过改变APP和tau基因的表达来实现的。
We have investigated the effect of genotypes of apolipoprotein E (ApoE) on the pathologies found in Alzheimer's disease (AD) and its related gene expression in 38 aged human brains obtained from consecutive autopsied cases. ApoE2/3, -3/3, -3/4, and -4/4 were typed in those aged brains, with ApoE3/3 being most prevalent. The AD pathologies were undetectable in ApoE2/3 brains, but were frequently observed in the other ApoE groups. In ApoE3/3 brains, 55%, 34%, and 24% of the cortical sections examined showed senile plaques (SPs), neurofibrillary tangles (NFTs), and cerebral amyloid angiopathy (CAA), respectively. In ApoE4/4 brains, the SP formation was significantly higher. The ApoE genotype neither affected ApoE, APP, or tau mRNA level, nor the differential expression of the latter two. These results suggest that ApoE4/4 accelerates and ApoE2/3 decelerates the development of the AD pathologies in the aged brain, but this is not through alterations of the APP and tau gene expression.