Cortical metabotropic glutamate receptors contribute to habituation of a simple odor-evoked behavior
Cortical metabotropic glutamate receptors contribute to habituation of a simple odor-evoked behavior
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DOI：
10.1523/jneurosci.5298-04.2005
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发表时间：
2005-03-09
影响因子：
5.3
通讯作者：
Wilson, DA
中科院分区：
文献类型：
--
作者：
Best, AR;Thompson, JV;Wilson, DA
定义参与特定行为的产生和停止的电路是神经科学的最终目标。短期行为习惯化是在重复呈现非强化刺激时发生的许多行为中观察到的反应衰减。在一些无脊椎动物短期行为习惯化的模型中，一个定义的突触的抑制被认为是机制。然而，短期行为习惯化的突触机制尚未在哺乳动物中确定。我们以前已经表明，突触前代谢型谷氨酸受体（mGluR）依赖性抑郁症的突触形成的嗅球传入梨状（嗅觉）皮质显着有助于适应皮质气味反应。在这里，我们表明，清醒的嗅觉皮层内的mGluRs的封锁，行为大鼠减少习惯的一个简单的气味诱导的行为，强烈暗示嗅觉的感觉门控的中枢机制。
Defining the circuits that are involved in production and cessation of specific behaviors is an ultimate goal of neuroscience. Short-term behavioral habituation is the response decrement observed in many behaviors that occurs during repeated presentation of non-reinforced stimuli. Within a number of invertebrate models of short-term behavioral habituation, depression of a defined synapse has been implicated as the mechanism. However, the synaptic mechanisms of short-term behavioral habituation have not been identified within mammals. We have shown previously that a presynaptic metabotropic glutamate receptor (mGluR)-dependent depression of synapses formed by olfactory bulb afferents to the piriform (olfactory) cortex significantly contributes to adaptation of cortical odor responses. Here we show that blockade of mGluRs within the olfactory cortex of awake, behaving rats diminishes habituation of a simple odor-induced behavior, strongly implicating a central mechanism for sensory gating in olfaction.