Serglycin: at the crossroad of inflammation and malignancy.
Serglycin: at the crossroad of inflammation and malignancy.
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DOI：
10.3389/fonc.2013.00327
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发表时间：
2014-01-13
影响因子：
4.7
通讯作者：
Theocharis AD
中科院分区：
文献类型：
--
作者：
Korpetinou A;Skandalis SS;Labropoulou VT;Smirlaki G;Noulas A;Karamanos NK;Theocharis AD
丝甘肽最初被表征为由造血细胞表达的细胞内蛋白聚糖。所有炎症细胞高度合成丝甘肽并将其储存在颗粒中，在颗粒中它与许多炎症介质相互作用，例如蛋白酶、趋化因子、细胞因子和生长因子。丝甘肽与它们在颗粒中的储存和它们的保护有关，因为它们作为复合物分泌并在分泌后递送至它们的靶标。在过去的十年中，许多研究表明，sergylycin也是由各种非造血细胞类型合成的。已经表明，sergylycin由肿瘤细胞高度表达，并促进其侵袭性表型，并赋予对药物和补体系统攻击的抗性。除了对肿瘤细胞的直接有益作用外，sergylycin还可促进肿瘤细胞微环境中的炎症过程，从而促进肿瘤的发展。在本综述中，我们讨论了sergylycin在炎症和肿瘤进展中的作用。
Serglycin has been initially characterized as an intracellular proteoglycan expressed by hematopoietic cells. All inflammatory cells highly synthesize serglycin and store it in granules, where it interacts with numerous inflammatory mediators, such as proteases, chemokines, cytokines, and growth factors. Serglycin is implicated in their storage into the granules and their protection since they are secreted as complexes and delivered to their targets after secretion. During the last decade, numerous studies have demonstrated that serglycin is also synthesized by various non-hematopoietic cell types. It has been shown that serglycin is highly expressed by tumor cells and promotes their aggressive phenotype and confers resistance against drugs and complement system attack. Apart from its direct beneficial role to tumor cells, serglycin may promote the inflammatory process in the tumor cell microenvironment thus enhancing tumor development. In the present review, we discuss the role of serglycin in inflammation and tumor progression.