Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans.
Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans.
复制标题
出版商更正：甲基化缺陷会扰乱从细菌到人类的生物节律。
DOI：
10.1038/s42003-020-1031-0
复制
发表时间：
2020
影响因子：
5.9
通讯作者：
Fustin JM
中科院分区：
文献类型：
--
作者：
Fustin JM
甲基循环是一种普遍的代谢途径，为核酸和蛋白质的甲基化提供甲基基团，调节细胞生理学的各个方面。我们以前已经表明，甲基循环抑制在哺乳动物强烈影响昼夜节律。由于甲基循环和生物钟在进化的早期就已经进化出来，并且在生命之树的生物体中运作，我们试图确定两者之间的联系是否也是保守的。在这里，我们表明，甲基循环抑制影响生物节律的物种，从单细胞藻类到人类，超过10亿年的进化分开。与此相反，蓝藻时钟是耐甲基循环抑制，虽然我们证明，甲基化本身调节这种生物体的昼夜节律。哺乳动物细胞与重新布线细菌样甲基循环的保护，如蓝藻，从甲基循环抑制，提供有趣的新的可能性，为治疗甲基化缺陷。
The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. Here, we show that methyl cycle inhibition affects biological rhythms in species ranging from unicellular algae to humans, separated by more than 1 billion years of evolution. In contrast, the cyanobacterial clock is resistant to methyl cycle inhibition, although we demonstrate that methylations themselves regulate circadian rhythms in this organism. Mammalian cells with a rewired bacteria-like methyl cycle are protected, like cyanobacteria, from methyl cycle inhibition, providing interesting new possibilities for the treatment of methylation deficiencies.