The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating
The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating
复制标题
镉基水相的细胞毒性 - 合成量子点及其表面涂层的调节
DOI：
10.1016/j.biomaterials.2008.09.029
复制
发表时间：
2009-01-01
期刊：
影响因子：
14
通讯作者：
Fan, Chunhai
中科院分区：
文献类型：
--
作者：
Su, Yuanyuan;He, Yao;Fan, Chunhai
在这份报告中，我们评估了一系列在水相中直接合成的量子点（QD）的细胞毒性，即，硫醇稳定的CdTe、CdTe/CdS核-壳结构的和CdTe/CdS/ZnS核-壳-壳结构的QD，具有多种细胞系，包括K562和HEK 293 T。我们已经证明，由于镉离子的释放，碲化镉量子点是高毒性的细胞。CdS层的外延生长在很小程度上降低了量子点的细胞毒性。然而，ZnS外层的存在极大地改善了量子点的生物相容性，即使在非常高的浓度和长时间暴露于细胞中也没有观察到细胞毒性。我们的系统研究清楚地表明，量子点的细胞毒性可以调制通过精心的表面涂层和CdTe/CdS/ZnS核-壳-壳结构的量子点直接在水相中合成的是非常有前途的生物荧光探针的细胞成像。(C)2008爱思唯尔有限公司版权所有。
In this report, we evaluated the cytotoxicity of a series of quantum dots (QDs) directly synthesized in aqueous phase, i.e., thiols-stabilized CdTe, CdTe/CdS core-shell structured and CdTe/CdS/ZnS core-shell-shell structured QDs, with a variety of cell lines including K562 and HEK293T. We have demonstrated that the CdTe QDs are highly toxic for cells due to the release of cadmium ions. Epitaxial growth of a CdS layer reduces the cytotoxicity of QDs to a small extent. However, the presence of a ZnS outlayer greatly improves the biocompatibility of QDs, with no observed cytotoxicity even at very high concentration and long-time exposure in cells. Our systematic investigation clearly shows that the cytotoxicity of QDs can be modulated through elaborate surface coatings and that the CdTe/CdS/ZnS core-shell-shell structured QDs directly synthesized in aqueous phase are highly promising biological fluorescent probes for cellular imaging. (C) 2008 Elsevier Ltd. All rights reserved.