Longitudinal analysis of cognitive performances and structural brain changes in late-life bipolar disorder
Longitudinal analysis of cognitive performances and structural brain changes in late-life bipolar disorder
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DOI：
10.1002/gps.2683
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发表时间：
2011-12-01
影响因子：
4
通讯作者：
Giannakopoulos, P.
中科院分区：
文献类型：
--
作者：
Delaloye, C.;Moy, G.;Giannakopoulos, P.
目的：双相情感障碍 (BD) 的横断面研究表明，边缘区域存在认知缺陷和微妙的磁共振成像 (MRI) 变化，这些变化可能在情绪正常阶段持续存在。认知和 MRI 变化是否代表 BD 的稳定属性或随时间演变仍存在争议。为了解决这个问题，我们进行了一项为期 2 年的纵向研究，包括对 15 名情绪正常的老年 BD 患者和 15 名对照者进行详细的神经心理学和磁共振成像 (MRI) 分析。方法：神经心理学评估涉及工作记忆、情景记忆、处理速度和执行功能。 MRI 分析包括灰质的基于体素的形态测量 (VBM) 分析，包括感兴趣区域 (ROI) 分析和扩散张量成像衍生的分数各向异性 (FA) 的白质的基于束的空间统计 (TBSS) 分析。结果：与对照组相比，BD 患者在处理速度和情景记忆方面表现出显着较低的表现，但在工作记忆和执行功能方面则不然。然而，在 2 年随访期间，BD 患者的认知变化平均轨迹与对照组没有差异。同样，BD 患者和对照组之间的纵向灰质 (VBM、ROI) 和白质 (TBSS FA) 变化没有差异。结论：BD 患者和对照组之间在认知和 MRI 结果的 2 年变化方面缺乏区别，这支持了这样的观点，即这种疾病不会对认知和大脑衰老产生显着的不利影响。从这个角度来看，目前的结果为双相情感障碍患者传达了希望的信息。版权所有 (C) 2011 John Wiley & Sons, Ltd.
Objectives: Cross-sectional studies in bipolar disorder (BD) suggested the presence of cognitive deficits and subtle magnetic resonance imaging (MRI) changes in limbic areas that may persist at euthymic stages. Whether or not cognitive and MRI changes represent stable attributes of BD or evolve with time is still matter of debate. To address this issue, we performed a 2-year longitudinal study including detailed neuropsychological and magnetic resonance imaging (MRI) analyses of 15 euthymic older BD patients and 15 controls.Methods: Neuropsychological evaluation concerned working memory, episodic memory, processing speed, and executive functions. MRI analyses included voxel-based morphometry (VBM) analysis of gray matter including region of interest (ROI) analysis and tract-based spatial statistics (TBSS) analysis of white matter of diffusion tensor imaging derived fractional anisotropy (FA).Results: BD patients displayed significantly lower performances in processing speed and episodic memory but not in working memory and executive functions compared to controls. However, BD patients did not differ from controls in the mean trajectory of cognitive changes during the 2 years follow-up. In the same line, longitudinal gray matter (VBM, ROI) and white matter (TBSS FA) changes did not differ between BD patients and controls.Conclusion: The lack of distinction between BD patients and controls in respect to the 2-year changes in cognition and MRI findings supports the notion that this disorder does not have a significant adverse impact on cognitive and brain aging. From this point of view, the present results convey a message of hope for patients suffering from BD. Copyright (C) 2011 John Wiley & Sons, Ltd.