Insights into cold tolerance in sable (Martes zibellina) from the adaptive evolution of lipid metabolism
Insights into cold tolerance in sable (Martes zibellina) from the adaptive evolution of lipid metabolism
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从脂质代谢的适应性进化深入了解紫貂（Martes zibellina）的耐冷性
DOI：
10.1007/s42991-021-00135-0
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发表时间：
2021-06
影响因子：
1.6
通讯作者：
Honghai Zhang
中科院分区：
文献类型：
--
作者：
Tian Xia;Lei Zhang;Guolei Sun;Xiufeng Yang;Chao Zhao;Honghai Zhang
紫貂（Martes zibellina）广泛分布于欧亚大陆北方带。zibellinasurvival比南方分布的貂类需要更好的调节体温的能力。紫貂适应性脂肪机制的遗传基础尚不清楚。我们筛选了与脂质代谢和吸收相关的候选基因，并将其与其他食肉动物的正向序列进行了比较。我们的目标是确定更薄的毛皮层背后的分子机制，并确定紫貂的寒冷适应是否与这些基因的进化变化有关。我们发现PNLIP和ACSS 2基因都受到了正向选择，GOT 2基因经历了快速进化。我们对紫貂脂肪组织进行了比较转录组测序，发现了多个表达水平不同的基因。差异表达基因的GO富集分析显示，它们在GO条目中显著富集，如脂质代谢、脂肪酶活性和葡萄糖代谢。KEGG富集分析显示，这些基因在代谢途径和脂肪酸代谢途径中显著富集，表明冬夏两季脂肪组织代谢水平存在显著差异。
The sable (Martes zibellina) is widely distributed in the northern zone of Eurasia.M. zibellinasurvival requires a better ability to regulate its body temperature than southern-distributed marten species. The genetic basis underlying the adaptive fat mechanism in the sable is unclear. We screened candidate genes related to lipid metabolism and absorption and compared these with orthologous sequences from other carnivores. Our goal was to determine the molecular mechanism underlying the thinner fur layer and determine if the cold adaptation of sables is associated with evolutionary changes in these genes. We found that thePNLIPandACSS2genes have received positive selection and theGOT2gene has undergone rapid evolution. We performed comparative transcriptome sequencing of the sable adipose tissue and found multiple genes with different expression levels. GO enrichment analysis on the differentially expressed genes showed that they were significantly enriched in GO entries, such as lipid metabolism, lipase activity, and glucose metabolism. KEGG enrichment analysis revealed that these genes were significantly enriched in metabolic pathways and fatty acid metabolism pathways, indicating significant differences in the metabolic level of adipose tissue in winter and summer.
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