Heat shock: the role of transient inducible responses in cell damage, transformation, and differentiation.
Heat shock: the role of transient inducible responses in cell damage, transformation, and differentiation.
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热休克：瞬时诱导反应在细胞损伤、转化和分化中的作用。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
R. Morimoto
中科院分区：
文献类型：
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作者：
R. Morimoto
应激反应在细菌界、植物界和动物界的所有生物体中普遍存在。这种反应的一个显著特征是合成一组离散的蛋白质，称为热休克蛋白，已被证明在过多的蛋白质生物合成和加工反应中是必不可少的，包括蛋白质折叠和寡聚、移位和分泌。在热休克和其他形式的生理应激中，热休克蛋白作为细胞内的哨兵识别错误折叠的蛋白。热休克反应受到严格的调控，包括选择性的转录和翻译机制，这些机制控制着生理应激过程中应激蛋白的优先合成。应激基因表达的失控与多种人类疾病有关。损伤蛋白分子和应激蛋白之间相互作用的平衡可能会对正常细胞的生长和分化产生深远的影响。
The stress response is ubiquitous among all organisms of the bacterial, plant, and animal kingdoms. A prominent feature of this response is the synthesis of a discrete set of proteins, known as heat shock proteins, that have been shown to be essential in a plethora of protein biosynthetic and processing reactions, including protein folding and oligomerization, translocation, and secretion. During heat shock and other forms of physiological stress, heat shock proteins act as intracellular sentinels to recognize malfolded proteins. The heat shock response is tightly regulated and encompasses selective transcriptional and translational mechanisms that control the preferential synthesis of stress proteins during physiological stress. Deregulation of stress gene expression is associated with various human diseases. It is likely that the balance of interactions between damaged protein molecules and stress proteins has profound effects that impinge on normal cell growth and differentiation.