Body Composition in Adolescents During Treatment With Selective Serotonin Reuptake Inhibitors
Body Composition in Adolescents During Treatment With Selective Serotonin Reuptake Inhibitors
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DOI：
10.1542/peds.2016-3943
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发表时间：
2017-07-01
期刊：
影响因子：
8
通讯作者：
Zemel, Babette S.
中科院分区：
文献类型：
--
作者：
Calarge, Chadi A.;Mills, James A.;Zemel, Babette S.
目的：研究独立的贡献，抑郁症（MDD），广泛性焦虑症（GAD），选择性5-羟色胺再摄取抑制剂（SSRIs）的身体组成的变化，在年长的adolescents.METHODS：医学健康的15- 20岁的年轻人谁是未经药物治疗或1个月内开始的SSRI进行了前瞻性随访。每月评估精神功能和药物治疗。每4个月测量一次体重指数（BMI）。每8个月进行一次全身双能X线吸收测量扫描，以确定瘦体重指数、脂肪质量指数和内脏脂肪质量。线性混合效应回归分析研究了MDD，GAD和SSRI使用变量和身体组成measurements.RESULTS：在1.51 +/- 0.76年的随访中，264名参与者提供了805个观察结果。在研究中调整年龄、性别、体力活动、饮食摄入和时间后，MDD严重程度与BMI、脂肪质量指数和瘦BMIz评分呈负相关，而累积SSRI治疗持续时间和剂量与这些结果呈正相关。GAD的严重程度和诊断与任何身体成分结果均无显着相关性。此外，西酞普兰和艾司西酞普兰与所有身体组成指标（包括内脏脂肪量）的增加相关性最强，而与氟西汀的相关性较弱。舍曲林与未接受SSRI治疗的情况没有什么不同。结论：平均1.5年内，抑郁严重程度与年龄较大的青少年身体成分指标的下降相关，而SSRI治疗与这些结果正相关，且各治疗组的效果有所不同。
OBJECTIVES: To examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) to changes in body composition in older adolescents.METHODS: Medically healthy 15-to 20-year-olds who were unmedicated or within 1 month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly. Body Mass Index (BMI) was measured every 4 months. Every 8 months, a whole-body dual-energy radiograph absorptiometry scan was obtained to determine lean BMI, fat mass index, and visceral fat mass. Linear mixed effects regression analysis examined associations between MDD, GAD, and SSRI use variables and body composition measures.RESULTS: Over 1.51 +/- 0.76 years of follow-up, 264 participants contributed 805 observations. After adjusting for age, sex, physical activity, dietary intake, and time in the study, MDD severity was inversely associated, prospectively, with BMI, fat mass index, and lean BMIz scores, whereas cumulative SSRI treatment duration and dose were positively associated with these outcomes. GAD severity and diagnosis were not significantly associated with any body composition outcome. Moreover, citalopram and escitalopram were most strongly associated with the increase in all body composition measures, including visceral fat mass, whereas the associations with fluoxetine were somewhat weaker. Sertraline was not different from no SSRI treatment.CONCLUSIONS: Depression severity was associated with a decrease in measures of body composition in older adolescents over a mean of 1.5 years, whereas SSRI treatment was positively associated with these outcomes, with differential effects across treatment groups.