Variation and symmetry in the lumbar and thoracic dorsal root ganglion cell populations of newly metamorphosed Xenopus laevis.
Variation and symmetry in the lumbar and thoracic dorsal root ganglion cell populations of newly metamorphosed Xenopus laevis.
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新变态的非洲爪蟾腰椎和胸椎背根神经节细胞群的变异和对称性。
DOI：
10.1002/cne.902920103
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Sperry,DG
中科院分区：
文献类型：
--
作者：
Sperry,DG
测量正常发育的新变态非洲爪蟾的腰椎和胸椎背根神经节细胞群的大小，以确定这些神经元群是否具有与后肢运动神经元群相同的特征；我。例如，巨大的个体和兄弟群体差异、显着的双侧对称性以及神经元数量和身体大小之间的粗略对应，表明正常发育过程中细胞数量的一些外周控制（Sperry，J. Comp. Neurol. 264：250-267）。在来自三个兄弟组的动物中，胸椎和腰椎神经节细胞的总数是高度可变且对称的，尽管对称性在各个神经节对的水平上并不均匀存在。兄弟姐妹组的神经元数量也存在显着差异。变态体的大小和胸神经节细胞数量显着相关，但腰神经节细胞数量没有显着相关。还对同一动物中支配后肢的运动神经元进行了计数和测量。虽然运动神经元数量和变态身体大小既可变又对称，但在三个兄弟群体中只有两个存在相关性。有趣的是，运动神经元和腰神经节细胞这两种神经元的数量，人们可能预测它们的大小在正常发育的动物中显着相关，但它们的数量并不相关。讨论了这些观察结果与当前关于正常发育过程中如何控制神经元数量的观点之间的关系。
The size of the lumbar and thoracic dorsal root ganglion cell populations in normally developing newly metamorphosedXenopus laeviswere measured in order to determine whether these neuron populations have the same characteristics as the hindlimb motoneuron population; i. e., large individual as well as sibling group differences, striking bilateral symmetry, and a rough correspondence between neuron number and body size that suggests some peripheral control of cell number during normal development (Sperry, J. Comp. Neurol. 264:250‐267). Among animals from three sibling groups, the total numbers of thoracic and lumbar ganglion cells are highly variable and symmetrical, although symmetry is not uniformly present at the level of individual ganglion pairs. Significant sibling group differences in neuron number are also present. Metamorphic body size and cell number in the thoracic but not in the lumbar ganglia are significantly correlated. The motoneurons innervating the hindlimbs were also counted and measured in the same animals. While variable as well as symmetrical, motoneuron number and metamorphic body size are correlated in only two of the three sibling groups. Interestingly, the numbers of motoneurons and lumbar ganglion cells, two populations of neurons whose sizes one might predict would be significantly correlated in normally developing animals, are not correlated. The relationship between these observations and currently held views concerning how neuron numbers might be controlled during normal development is discussed.