GENE MAP OF THE COW - CONSERVATION OF LINKAGE WITH MOUSE AND MAN
GENE MAP OF THE COW - CONSERVATION OF LINKAGE WITH MOUSE AND MAN
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DOI：
10.1093/oxfordjournals.jhered.a110160
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发表时间：
1986-01-01
影响因子：
3.1
通讯作者：
MOLL, YD
中科院分区：
文献类型：
--
作者：
WOMACK, JE;MOLL, YD
采用纤维素-醋酸电泳技术对分离牛染色体的牛-仓鼠杂交体细胞进行了28个酶基因产物的分析，其中包括先前未分配的GAPD、ITPA、ADA、ACO1、GDH、GUK、CAT和GLO1位点。这28个位点被组织成21个独立的同基因群，使牛基因图谱在24个同基因群上达到35个位点。现在已经在人类、老鼠和牛身上发现了32个同源基因。在这32个位点中，只有3个位点不一致，而在人类和小鼠的相同位点中有9个位点不一致，这证明了牛和人类连锁群的保守性。
Cattle-hamster hybrid somatic cells segregating cattle chromosomes have been analyzed by cellulose-acetate electrophoresis for 28 enzyme gene products including the previously unassigned loci for GAPD, ITPA, ADA, ACO1, GDH, GUK, CAT, and GLO1. These 28 loci are organized into 21 independent syntenic groups bringing the composite bovine gene map to 35 loci on 24 syngenic groups. Thirty-two homologous genes now have been mapped in humans, mice, and cattle. Conservation of cattle and human linkage groups is evidenced by only three linkage discordancies among these 32 loci as contrasted to nine discordancies among the same loci in the human and mouse maps.