Does chlorhexidine reduce bacteremia following tooth extraction? A systematic review and meta-analysis
Does chlorhexidine reduce bacteremia following tooth extraction? A systematic review and meta-analysis
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DOI：
10.1371/journal.pone.0195592
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发表时间：
2018-04-23
期刊：
影响因子：
3.7
通讯作者：
Ramos, Eva
中科院分区：
文献类型：
--
作者：
Arteagoitia, Iciar;Rodriguez Andres, Carlos;Ramos, Eva
背景和目的关于拔牙前使用抗菌漱口水以减少菌血症的科学证据尚不清楚。我们测试的零假设，将有没有差异的发病率菌血症拔牙后的患者接受或不洗必泰。材料和methodsWe进行了荟萃分析后提出的建议PRISMA首选报告项目的系统评价和荟萃分析。检索了Pubmed、科克伦、Web of Science、Science Direct、Scopus和奥维德医学博士的数据源，直至2017年4月30日。在自由文本检索中，使用（洗必泰）和（菌血症或菌血症）和（浸提或清除）作为关键词。检索已发表的会议摘要。对每篇文献的参考文献进行了综述。我们只纳入了随机对照临床试验。对出版的语言或日期没有任何限制。结果测量是在拔牙后前10分钟内测量的菌血症发生率。两名评审员独立进行偏倚风险评估和数据提取。结果在18项研究中，有8项符合条件的试验，共523名受试者，其中实验组267名，对照组256名：风险比= 0.882（95%置信区间0.799 - 0.975; p = 0.014），异质性I-2 = 13.07%，p = 0.33。需要治疗的人数为16（95%CI 7-Infinity）。ConclusionsAbout 12%的菌血症病例可以预防，如果人口暴露于洗必泰。CRD42016046586。
Background and aimsScientific evidence is not clear regarding the use of antimicrobial mouth rinse before dental extraction to reduce bacteremia. We tested the null hypothesis that there would be no difference in the incidence of bacteremia following dental extractions in patients treated with or without chlorhexidine.Material and methodsWe conducted a meta-analysis following the recommendations proposed by PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The data sources Pubmed, Cochrane, Web of Science, Science Direct, Scopus, and Ovid MD were searched until April 30, 2017. (chlorhexidine) AND (bacteremia OR bacteraemia) AND (extraction OR removal) were used as key words in a free-text search. Published meeting abstracts were searched. The references of each article were reviewed. We only included randomized controlled clinical trials. There were no restrictions regarding language or date of publication. The outcome measure was the incidence of the bacteremia measured within the first ten minutes post-extraction. Two reviewers independently undertook the risk of bias assessment and data extraction. A fixed-effects inverse variance weighted meta-analysis was conducted.ResultsOut of 18 studies, eight eligible trials with 523 participants were selected, 267 in the experimental group and 256 in the control group: risk ratio = 0.882 (95% confidence interval 0.799 to 0.975; p = 0.014), heterogeneity I-2 = 13.07%, and p = 0.33. The number needed to treat was 16 (95% CI 7-Infinity).ConclusionsApproximately 12% of bacteremia cases can be prevented if a population is exposed to chlorhexidine. CRD42016046586.