Trait antagonism and the progression of arterial thickening: women with antagonistic traits have similar carotid arterial thickness as men.
Trait antagonism and the progression of arterial thickening: women with antagonistic traits have similar carotid arterial thickness as men.
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特质拮抗和动脉增厚的进展：具有拮抗特质的女性的颈动脉厚度与男性相似。
DOI：
10.1161/hypertensionaha.110.155317
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Terracciano,Antonio
中科院分区：
文献类型：
--
作者：
Sutin,AngelinaR;Scuteri,Angelo;Lakatta,EdwardG;Tarasov,KirillV;Ferrucci,Luigi;CostaJr,PaulT;Schlessinger,David;Uda,Manuela;Terracciano,Antonio
大量的证据将对抗相关的特质与心血管结局联系起来，但对心理特质如何与心血管疾病的中间标志物相关知之甚少。本研究使用来自意大利撒丁岛的大型社区样本（n=5614），研究了特质对抗（低宜人性）及其方面与颈动脉内膜中层厚度（动脉增厚的测量）的关系。控制人口统计学和心血管危险因素，低宜人性，特别是低直率性和低依从性，与颈动脉增厚，同时和前瞻性测量，并增加内膜中层厚度超过3年。事实上，那些在宜人性中处于最后10%的人，内膜中层厚度增加的风险增加了40%。虽然男性动脉壁较厚，但具有拮抗性特征的女性颈动脉增厚与拮抗性男性相似。对抗性个体，特别是那些操纵性和攻击性的个体，动脉增厚的增加更大，与传统的心血管危险因素无关。
A large body of evidence links antagonism-related traits with cardiovascular outcomes, but less is known about how psychological traits are associated with intermediate markers of cardiovascular disease. Using a large, community-based sample from Sardinia, Italy (n=5614), this study examined how trait antagonism (low agreeableness) and its facets are associated with carotid artery intima-media thickness, a measure of arterial thickening. Controlling for demographic and cardiovascular risk factors, low agreeableness and, in particular, low straightforwardness and low compliance, were associated with greater carotid thickening, measured concurrently and prospectively, and with increases in intima-media thickness over 3 years. Indeed, those in the bottom 10% of agreeableness had a 40% increase in risk for elevated intima-media thickness. Although men have thicker arterial walls, women with antagonistic traits had similar carotid thickening as antagonistic men. Antagonistic individuals, especially those who are manipulative and aggressive, have greater increases in arterial thickening, independent of traditional cardiovascular risk factors.