Otolith inputs to pursuit neurons in the frontal eye fields of alert monkeys
Otolith inputs to pursuit neurons in the frontal eye fields of alert monkeys
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DOI：
10.1007/s00221-008-1644-x
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发表时间：
2009-03-01
影响因子：
2
通讯作者：
Fukushima, Kikuro
中科院分区：
文献类型：
--
作者：
Akao, Teppei;Kurkin, Sergei;Fukushima, Kikuro
平滑追踪系统必须与前庭系统相互作用，以在头部运动期间保持眼睛运动在空间中的准确性。不仅在主要激活半圆形管的头部旋转期间，而且在激活耳石器官的头部平移期间，都需要在中央凹上维持目标图像。额叶眼野尾侧部分含有追踪神经元。他们中的大多数接受由全身旋转引起的前庭输入。然而，还没有测试FEF追踪神经元是否接收耳石输入。在本研究中，我们首先分类FEF追求神经元属于三个组之一（聚散度+额平行追求，聚散度，额平行追求只）的基础上，他们的反应在额平行追求和正中矢状聚散追求。然后，我们通过以0.33 Hz（+/- 10 cm，峰值速度19 cm/s; 0.04 g）被动地正弦移动整个身体来测试这些神经元在前/后和/或右/左平移期间的放电调制。所有三组中的大多数FEF追踪神经元在完全黑暗中被前/后和右/左平移激活，而没有目标。放电调制幅度与平移前庭眼反射（VOR）无相关性。首选方向的翻译反应几乎均匀地分布在前面的猴子。当靶与全身一起移动时，也观察到放电调制，要求猴子取消平移VOR。这些结果表明，在整个身体平移过程中的FEF追踪神经元的放电调制反映耳石输入。
The smooth-pursuit system must interact with the vestibular system to maintain the accuracy of eye movements in space during head movement. Maintenance of a target image on the foveae is required not only during head rotation which activates primarily semi-circular canals but also during head translation which activates otolith organs. The caudal part of the frontal eye fields (FEF) contains pursuit neurons. The majority of them receive vestibular inputs induced by whole body rotation. However, it has not been tested whether FEF pursuit neurons receive otolith inputs. In the present study, we first classified FEF pursuit neurons as belonging to one of three groups (vergence + fronto-parallel pursuit, vergence only, fronto-parallel pursuit only) based on their responses during fronto-parallel pursuit and mid-sagittal vergence-pursuit. We, then, tested discharge modulation of these neurons during fore/aft and/or right/left translation by passively moving the whole body sinusoidally at 0.33 Hz (+/- 10 cm, peak velocity 19 cm/s; 0.04g). The majority of FEF pursuit neurons in all three groups were activated by fore/aft and right/left translation without a target in complete darkness. There was no correlation between the magnitude of discharge modulation and translational vestibulo-ocular reflex (VOR). Preferred directions of translational responses were distributed nearly evenly in front of the monkeys. Discharge modulation was also observed when a target moved together with whole body, requiring the monkeys to cancel the translational VOR. These results indicate that the discharge modulation of FEF pursuit neurons during whole body translation reflected otolith inputs.