Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: a surface-mediated transformation
Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: a surface-mediated transformation
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DOI：
10.1039/c6ce00521g
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发表时间：
2016-01-01
期刊：
影响因子：
3.1
通讯作者：
Manuel Delgado-Lopez, Jose
中科院分区：
文献类型：
--
作者：
Chatzipanagis, Konstantinos;Iafisco, Michele;Manuel Delgado-Lopez, Jose
这项工作结合原位和异位表征技术，探索了柠檬酸盐功能化无定形磷酸钙 (cit-ACP) 在两种相关介质中结晶的机制。结果表明，cit-ACP 的柠檬酸盐解吸触发了表面介导的纳米晶磷灰石 (Ap) 转化。我们的研究结果揭示了柠檬酸盐（骨有机基质的重要成分）以及介质成分在控制转化速率和所得Ap相形态方面的关键作用。
This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situ and ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.