By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.
By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.
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通过招募 HDAC1，MORC2 抑制胃癌中的 p21 Waf1/Cip1。
DOI：
10.18632/oncotarget.3889
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发表时间：
2015-06-30
期刊：
影响因子：
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通讯作者：
Wang G
中科院分区：
文献类型：
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作者：
Zhang Q;Song Y;Chen W;Wang X;Miao Z;Cao L;Li F;Wang G
微小支原体(MORC)家族CW型锌指蛋白2(MORC2)在DNA损伤反应中调节染色质重构，抑制基因转录，促进脂肪生成。在这里，我们发现MORC2通过将HDAC1招募到p21启动子上，以一种不依赖于p53的方式下调p21。MORC2介导的p21下调反过来又促进了胃癌细胞的细胞周期进程。此外，胃癌组织中MORC2的表达与p21的表达呈负相关。我们认为MORC2可能是一个潜在的癌症治疗靶点。
Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediated down-regulation of p21 in turn promoted cell cycle progression in gastric cancer cells. Furthermore, MORC2 expression correlated negatively with p21 expression in gastric tumors in patients. We suggest that MORC2 may be a potential therapeutic target in cancer.