ELEVATED BRONCHOALVEOLAR LAVAGE FLUID HISTAMINE LEVELS IN ALLERGIC ASTHMATICS ARE ASSOCIATED WITH INCREASED AIRWAY-OBSTRUCTION
ELEVATED BRONCHOALVEOLAR LAVAGE FLUID HISTAMINE LEVELS IN ALLERGIC ASTHMATICS ARE ASSOCIATED WITH INCREASED AIRWAY-OBSTRUCTION
复制标题
DOI：
10.1164/ajrccm/144.1.83
复制
发表时间：
1991-07-01
期刊：
影响因子：
--
通讯作者：
BUSSE, WW
中科院分区：
文献类型：
--
作者：
JARJOUR, NN;CALHOUN, WJ;BUSSE, WW
对 61 个样本的支气管肺泡灌洗 (BAL) 液中的组胺和类胰蛋白酶水平进行了评估（46 个样本来自 24 名特应性哮喘患者，7 个样本来自 7 名过敏性鼻炎患者，8 个样本来自 8 名正常志愿者）。 哮喘患者和过敏性鼻炎患者的 BAL 组胺含量显着高于正常受试者（分别为 169 +/- 22、141 +/- 23、42 +/- 6 pg/ml；p < 0.05，两种比较）。 哮喘患者和过敏性鼻炎患者的 BAL 液体类胰蛋白酶水平也高于正常受试者（分别为 0.36 +/- 0.03、0.38 +/- 0.05、0.23 +/- 0.04 ng/ml；p < 0.05，两种比较）；然而，BAL 中的类胰蛋白酶和组胺水平并不相关（整个组中 r = -0.03，哮喘组中 r = -0.12）。 哮喘组中 BAL 组胺浓度与预测的 FEV1 百分比呈反比（r = -0.44，p < 0.005）。 BAL 液组胺水平较高（大于或等于 100 pg/ml，n = 23）的哮喘患者的 FEV1 预测百分比较低（80 +/- 3% 与 96 +/- 3%，p = 0.0005），FEV1/FVC 比率较低（72 +/- 1% 与 77 +/- 2%，p < 0.05），BAL 百分比较高与 BAL 液组胺水平较低的哮喘患者 (< 100 pg/ml，n = 23）。 这些数据表明 BAL 组胺浓度与哮喘气道阻塞相关，并可作为严重程度的指标。 BAL 类胰蛋白酶和组胺之间缺乏相关性可能表明肺嗜碱性粒细胞，而不是肥大细胞，可能是这些患者中组胺的来源。
Bronchoalveolar lavage (BAL) fluid was evaluated for histamine and tryptase levels in 61 samples (46 samples from 24 atopic asthmatics, seven samples from seven patients with allergic rhinitis, and eight samples from eight normal volunteers). Asthmatics and patients with allergic rhinitis had significantly higher BAL histamine than did normal subjects (169 +/- 22, 141 +/- 23, 42 +/- 6 pg/ml, respectively; p < 0.05, both comparisons). BAL fluid tryptase levels were also higher in asthmatics and patients with allergic rhinitis than in normal subjects (0.36 +/- 0.03, 0.38 +/- 0.05, 0.23 +/- 0.04 ng/ml, respectively; p < 0.05, both comparisons); however, levels of tryptase and histamine in BAL were not correlated (r = -0.03 in the group as a whole, r = -0.12 in the asthmatic group). BAL concentration of histamine correlated inversely with FEV1 percent predicted in the asthmatic group (r = -0.44, p < 0.005). Asthmatics with high BAL fluid histamine (greater-than-or-equal-to 100 pg/ml, n = 23) had lower FEV1 percent predicted (80 +/- 3% versus 96 +/- 3%, p = 0.0005), lower FEV1/FVC ratio (72 +/- 1% versus 77 +/- 2%, p < 0.05), higher percentage of BAL eosinophils (2.2 +/- 0.4% versus 0.6 +/- 0.1%, p < 0.002), and greater airway responsiveness (lower PD20 [13.1 +/- 3.4 versus 41.5 +/- 13.7 cumulative breath units, p < 0.05]) compared with asthmatics with low BAL fluid histamine (< 100 pg/ml, n = 23). These data indicate that BAL histamine concentrations are correlated with airway obstruction in asthma and may serve as an index of severity. The lack of correlation between BAL tryptase and histamine may indicate that pulmonary basophils, rather than mast cells, could be the source for histamine in these patients.