Serum S100B and antioxidant enzymes in bipolar patients
Serum S100B and antioxidant enzymes in bipolar patients
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DOI：
10.1016/j.jpsychires.2006.07.013
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发表时间：
2007-09-01
影响因子：
4.8
通讯作者：
Goncalves, Carlos Alberto
中科院分区：
文献类型：
--
作者：
Andreazza, Ana Cristina;Cassini, Carina;Goncalves, Carlos Alberto
双相情感障碍（BD）是一种慢性、严重和高度致残的精神疾病；外周标志物已被用于评估与双相障碍相关和/或可能参与其病理生理的生化改变。除了神经元的作用外，许多研究小组还提出神经胶质活动与精神疾病有关。其他生化标志物，特别是与氧化应激相关的，也在BD中得到了研究。在本研究中，我们评估了BD患者的神经胶质受累和氧化应激。采用血清硫代巴比妥酸活性物质（TBARS）和抗氧化酶活性对不同发作期BD患者的氧化应激进行评估。我们发现在躁狂和抑郁发作时血清S100B显著增加，但在心境正常的患者中没有。躁狂和抑郁患者的超氧化物歧化酶（SOD）活性以及SOD/谷胱甘肽过氧化物酶加过氧化氢酶的比值均升高。另一方面，与疾病的阶段无关，BD患者的TBARS水平升高。这些发现提示BD患者存在潜在的氧化损伤。这种外周氧化失衡表明在疾病的活跃期发生了系统性的变化。这些变化似乎与星形胶质细胞功能有关，如血清S100B升高所示。(c) 2006年Elsevier Ltd出版
Bipolar disorder (BD) is a chronic, severe, and highly disabling psychiatric disorder; peripheral markers have been used to assess biochemical alterations associated with BD and/or possibly involved in its pathophysiology. Beyond neuronal commitment, many groups have proposed the involvement of glial activity in psychiatric disorders. Other biochemical markers, particularly associated with oxidative stress, have been studied in BD. In the present study, we evaluated glial involvement and oxidative stress in patients with BD. Glial activity was assessed by measuring serum S100B content; oxidative stress was assessed using serum thiobarbituric acid reactive substances (TBARS) and activities of antioxidant enzymes in BD patients during different episodes of disease. We found a significant increment of serum S100B during episodes of mania and depression, but not in euthymic patients. Superoxide dismutase (SOD) activity, as well the SOD/glutathione peroxidase plus catalase ratio, was also increased in manic and depressed patients. On the other hand, TBARS levels were increased in BD patients regardless of the phase of the disorder. These findings suggest a potential oxidative damage in BD patients. This peripheral oxidative imbalance indicates that systemic changes are taking place during the active phases of the illness. Such changes appear to relate to astrocyte function, as indicated by serum S100B elevation. (c) 2006 Published by Elsevier Ltd.