Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'
Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'
复制标题
DOI：
10.1111/j.1440-1819.2005.01404.x
复制
发表时间：
2005-08-01
影响因子：
11.9
通讯作者：
Kato, T
中科院分区：
文献类型：
--
作者：
Kazuno, AA;Munakata, K;Kato, T
虽然经典的精神病理学研究已经显示存在独立的诊断类别，“非典型精神病”，但根据精神障碍诊断和统计手册（第4版; DSM-IV）标准，大多数精神病患者目前被分为两个主要的诊断类别，精神分裂症和双相情感障碍。“非典型精神病”的特征是没有系统性妄想的急性精神错乱、情绪不稳定和精神兴奋或昏迷。这些临床特征类似于器质性精神综合征，鉴别诊断往往很困难。由于线粒体肌病、脑病、乳酸酸中毒和中风样发作（MELAS）患者有时会表现出器质性精神障碍，因此在某些患者中，“非典型精神病”可能由线粒体DNA（mtDNA）突变引起。在本研究中，全mtDNA测序的7例患者与各种精神障碍，谁可以被归类为“非典型精神病”。他们中没有一个已知的线粒体DNA突变致病线粒体脑病。7例患者中有2例属于频率较低的单倍型群F1 b1 a。这些结果并不支持这一假设，即临床表现的一些患者与“非典型精神病”是一个亚临床线粒体脑病的反映。但F1 b1 a亚单倍群可能是“非典型精神病”关联研究的一个好靶点。
Although classical psychopathological studies have shown the presence of an independent diagnostic category, 'atypical psychosis', most psychotic patients are currently classified into two major diagnostic categories, schizophrenia and bipolar disorder, by the Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV) criteria. 'Atypical psychosis' is characterized by acute confusion without systematic delusion, emotional instability, and psychomotor excitement or stupor. Such clinical features resemble those seen in organic mental syndrome, and differential diagnosis is often difficult. Because patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) sometimes show organic mental disorder, 'atypical psychosis' may be caused by mutations of mitochondrial DNA (mtDNA) in some patients. In the present study whole mtDNA was sequenced for seven patients with various psychotic disorders, who could be categorized as 'atypical psychosis'. None of them had known mtDNA mutations pathogenic for mitochondrial encephalopathy. Two of seven patients belonged to a subhaplogroup F1b1a with low frequency. These results did not support the hypothesis that clinical presentation of some patients with 'atypical psychosis' is a reflection of subclinical mitochondrial encephalopathy. However, the subhaplogroup F1b1a may be a good target for association study of 'atypical psychosis'.