Mitochondria: in sickness and in health.
Mitochondria: in sickness and in health.
复制标题
线粒体：在疾病和健康中。
DOI：
10.1016/j.cell.2012.02.035
复制
发表时间：
2012-03-16
期刊：
影响因子：
64.5
通讯作者：
Suomalainen A
中科院分区：
文献类型：
--
作者：
Nunnari J;Suomalainen A
线粒体发挥着不同但相互关联的功能，产生三磷酸腺苷和许多生物合成中间体，同时也参与细胞应激反应，如自噬和细胞凋亡。线粒体形成一个动态的、相互连接的网络，与其他细胞隔间紧密结合。此外，线粒体的功能超越了细胞的边界，通过调节细胞和组织之间的通讯来影响生物体的生理。因此，线粒体功能障碍成为包括神经退行性疾病和代谢障碍在内的无数疾病的关键因素也就不足为奇了。我们提供了线粒体功能如何影响健康和疾病的最新观点。
Mitochondria perform diverse yet interconnected functions, producing ATP and many biosynthetic intermediates while also contributing to cellular stress responses such as autophagy and apoptosis. Mitochondria form a dynamic, interconnected network that is intimately integrated with other cellular compartments. In addition, mitochondrial functions extend beyond the boundaries of the cell and influence an organism’s physiology by regulating communication between cells and tissues. It is therefore not surprising that mitochondrial dysfunction has emerged as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders. We provide a current view of how mitochondrial functions impinge on health and disease.