Risk Factors for Chronic Atrial Fibrillation Development After Esophagectomy for Esophageal Cancer
Risk Factors for Chronic Atrial Fibrillation Development After Esophagectomy for Esophageal Cancer
复制标题
食管癌食管切除术后发生慢性心房颤动的危险因素
DOI：
10.1007/s11605-022-05493-9
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发表时间：
2022
影响因子：
3.2
通讯作者：
Yamaue Hiroki
中科院分区：
文献类型：
--
作者：
Kashiwagi Manabu;Ojima Toshiyasu;Hayata Keiji;Kitadani Junya;Takeuchi Akihiro;Kuroi Akio;Terada Kosei;Tanimoto Takashi;Tanaka Atsushi;Yamaue Hiroki
背景本研究探讨食管癌术后心房颤动（POAF）患者的预后，旨在阐明食管癌术后慢性期心房颤动（AF）发生的预测因素。方法回顾性分析2010年7月至2021年12月期间连续415例计划行食管癌食管切除术且无af病史的患者。结果73例（18%）患者发生spoaf。年龄明显高于无POAF组（72岁[66 ~ 77]vs 68岁[62 ~ 75]，P< 0.01）。三野区淋巴结清扫在POAF患者中更为常见（63% vs 50%，P= 0.04）。III/IV期癌症合并POAF与不合并POAF患者的总生存率差异无统计学意义（P= 0.37），但I/II期癌症合并POAF患者的总生存率低于未合并POAF患者（P= 0.03）。食管切除术后31天房颤复发或新发17例（4.1%）。POAF是慢性期房颤发展的唯一独立预测因子（HR: 4.09, 95%CI: [1.42-11.74]，P= 0.01）。合并POAF者8例（11.0%），未合并POAF者9例（2.6%）发生慢性期房颤（P< 0.01）。III/IV期肿瘤患者房颤发生率差异无统计学意义（P= 0.05），而I/II期肿瘤患者房颤发生率差异有统计学意义（P< 0.01）。结论食管切除术后POAF的发生与AF的未来发展及总生存预后有关。未来的研究必须确定最佳的治疗策略。
BackgroundThis study investigates the prognosis of patients with postoperative atrial fibrillation (POAF), aiming to elucidate predictors of occurrence of atrial fibrillation (AF) in the chronic phase after esophagectomy.MethodsWe retrospectively analyzed 415 consecutive patients between July 2010 and December 2021 who were scheduled to undergo esophagectomy for esophageal cancer and had no previous history of AF.ResultsPOAF occurred in 73 patients (18%). Their ages were higher than those without POAF (72 [66–77] vs 68 [62–75],P< 0.01). Three-field lymph node dissection was more frequent in patients with POAF (63% vs 50%,P= 0.04). Overall survival rates were not significantly different between those with and without POAF in patients with stage III/IV cancer (P= 0.37), but overall survival rate of patients with POAF was lower than in those without POAF in stage I/II cancer (P= 0.03). Seventeen patients (4.1%) had recurrence of AF or new onset 31 days after esophagectomy. POAF was the only independent predictor of AF development in the chronic phase (HR: 4.09, 95%CI: [1.42–11.74],P= 0.01). AF development in the chronic phase was observed in 8 patients (11.0%) with and 9 patients (2.6%) without POAF (P< 0.01). AF development rates were not significantly different in patients with stage III/IV cancer (P= 0.05), but there was significant difference in patients with stage I/II cancer (P< 0.01).ConclusionThe occurrence of POAF after esophagectomy is related with future development of AF and overall survival prognosis. Future studies must ascertain optimal therapeutic strategy.
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影响因子：
2.6
作者：
Stippel, DL;Taylan, C;Hölscher, AH
通讯作者：
Hölscher, AH
影响因子：
24
作者：
Butt, Jawad H.;Olesen, Jonas B.;Fosbol, Emil L.
通讯作者：
Fosbol, Emil L.
DOI：
10.1016/s1062-1458(01)00458-5
发表时间：
2001-11
期刊：
JAMA
影响因子：
--
作者：
B. Gage;A. Waterman;W. Shannon;M. Boechler;M. Rich;M. Radford
通讯作者：
B. Gage;A. Waterman;W. Shannon;M. Boechler;M. Rich;M. Radford
影响因子：
2.4
作者：
Nagatsuka, Yuta;Sugimura, Keijiro;Yano, Masahiko
通讯作者：
Yano, Masahiko
DOI：
10.1016/s0022-5223(03)00974-7
发表时间：
2003-10-01
影响因子：
6
作者：
Murthy, SC;Law, S;Wong, J
通讯作者：
Wong, J