Influence of elevated liver fat on circulating adipocytokines and insulin resistance in obese Hispanic adolescents.
Influence of elevated liver fat on circulating adipocytokines and insulin resistance in obese Hispanic adolescents.
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DOI：
10.1111/j.2047-6310.2011.00014.x
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发表时间：
2012-04
影响因子：
3.8
通讯作者：
Goran MI
中科院分区：
文献类型：
--
作者：
Kim JS;Lê KA;Mahurkar S;Davis JN;Goran MI
We performed this study to examine the metabolic differences arising from higher liver fat accumulation in obese Hispanic adolescents, with a particular focus on circulating levels of adipocytokines and insulin resistance. Forty-one obese Hispanic adolescents (15.3 ± 1.0 years, body mass index percentile: 97.0 ± 3.9) were assessed for: visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and hepatic fat fraction (HFF) by magnetic resonance imaging; fasting measures of serum glucose, insulin and adipocytokines; homeostasis model assessment of insulin resistance (HOMA-IR); and insulin sensitivity (SI) and the acute insulin response to glucose (AIR) by intravenous glucose tolerance test. Subjects with normal levels of HFF (below 5%; n = 25) were compared to those with HFF > 5% (n = 16). The two groups differing in HFF were similar for total body fat, VAT and SAT. The group with HFF > 5% had significantly (P < 0.05) higher interleukin-8 (IL-8) (6.1 ± 1.6 vs. 3.2 ± 0.4 pg mL−1), NGF (30.2 ± 9.9 vs. 13.9 ± 1.6 pg mL−1), HOMA-IR (8.8 ± 1.1 vs. 5.5 ± 0.5), AIR (1869 ± 206 vs. 1092 ± 165) and a tendency for lower SI (1.2 ± 0.4 vs. 2.1 ± 0.3; P = 0.06), with no significant differences in any of other factors measured. These data suggest that elevated liver fat is most closely associated with elevated serum IL-8 and NGF levels as well as increased AIR and HOMA-IR. These elevated factors may play significant roles in the metabolic abnormalities associated with elevated liver fat in obese Hispanics.
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影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH
影响因子：
13.5
作者：
Loomba, Rohit;Sirlin, Claude B.;Schwimmer, Jeffrey B.;Lavine, Joel E.
通讯作者：
Lavine, Joel E.
影响因子：
5.1
作者：
Mandato, C;Lucariello, S;Vajro, P
通讯作者：
Vajro, P
影响因子：
7.7
作者：
Taksali, Sara E.;Caprio, Sonia;Weiss, Ram
通讯作者：
Weiss, Ram
影响因子：
2.9
作者：
YOSHIDA, K;GAGE, FH
通讯作者：
GAGE, FH