Structure-activity relationship studies of curcumin analogues
Structure-activity relationship studies of curcumin analogues
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DOI：
10.1016/j.bmcl.2009.01.104
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发表时间：
2009-04-01
影响因子：
2.7
通讯作者：
Li, Pui-Kai
中科院分区：
文献类型：
--
作者：
Fuchs, James R.;Pandit, Bulbul;Li, Pui-Kai
本文合成了两个系列的姜黄素类似物，共二十四个化合物，并对其进行了评价。最有效的化合物，化合物23，显示出对前列腺癌和乳腺癌细胞系的有效生长抑制活性，IC 50值在亚微摩尔范围内，比姜黄素有效50倍。姜黄素类似物可能是潜在的乳腺癌和前列腺癌的抗肿瘤药物。(C)2009爱思唯尔有限公司保留所有权利。
Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast cancer lines with IC50 values in sub-micromolar range,fifty times more potent than curcumin. Curcumin analogues might be potential anti-tumor agents for breast and prostate cancers. (C) 2009 Elsevier Ltd. All rights reserved.