Comparison of complications during 1-year follow-up between remitting seronegative symmetrical synovitis with pitting edema syndrome and elderly-onset rheumatoid arthritis
Comparison of complications during 1-year follow-up between remitting seronegative symmetrical synovitis with pitting edema syndrome and elderly-onset rheumatoid arthritis
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缓解型血清阴性对称性滑膜炎伴凹陷性水肿综合征与老年类风湿性关节炎1年随访并发症比较
DOI：
10.1080/25785826.2022.2046307
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发表时间：
2022
影响因子：
4.4
通讯作者：
Kawakami Atsushi
中科院分区：
文献类型：
--
作者：
Origuchi Tomoki;Umeda Masataka;Koga Tomohiro;Kawashiri Shin-ya;Iwamoto Naoki;Ichinose Kunihiro;Tamai Mami;Tsukada Toshiaki;Miyashita Taiichiro;Iwanaga Nozomi;Horai Yoshiro;Arima Kazuhiko;Aramaki Toshiyuki;Ueki Yukitaka;Eguchi Katsumi;Kawakami Atsushi
缓解性血清阴性对称性滑膜炎凹陷性水肿综合征(RS3PE)是一种影响老年人的风湿性疾病，对皮质激素反应良好；然而，我们的RS3PE患者的皮质类固醇治疗时间比预期的要长。据报道，老年起病的类风湿性关节炎(EORA)患者发生类固醇相关副作用的风险显著增加，包括心血管疾病(CVDS)。为了阐明接受皮质类固醇治疗的RS3PE患者与EORA患者在1年随访期间的并发症。回顾分析47例(男28例，女19例，年龄78.4 ± 7.5岁)和46例(男10例，女36例；年龄77.0 ± 6.8岁)R3PE患者术后1年随访的并发症。RS3PE组和EORA组的平均初始剂量分别为16.5 ± 7.2 mg/d和7.3 ± 4.6 mg/d。在治疗后的一年随访中，两组患者的心血管疾病均未见明显增加。然而，9例RS3PE患者发生感染，明显高于EORA合并感染的患者(n= 3)。初始PSL剂量是与感染发生率相关的自变量。老年RS3PE患者激素治疗期间感染明显增加。糖皮质激素的初始剂量是感染的危险因素。关键信息在类固醇治疗期间，老年RS3PE综合征患者的感染增加。
Remitting seronegative symmetrical synovitis with pitting edema syndrome (RS3PE), a rheumatic disease affecting the elderly, responds well to corticosteroids; however, our RS3PE patients' corticosteroid therapy is longer than expected. Elderly-onset rheumatoid arthritis (EORA) patients are reported to be at a significantly increased risk for steroid-related side effects including cardiovascular diseases (CVDs). To clarify the complications during a 1-year follow-up in corticosteroid-treated RS3PE patients compared to EORA patients. We retrospectively analyzed the records of 47 RS3PE patients (28 men, 19 women, age 78.4 ± 7.5 years) and 46 EORA patients (10 men, 36 women; 77.0 ± 6.8 yrs) to compare the complications over a 1-year follow-up. The RS3PE and EORA groups' average initial PSL doses were 16.5 ± 7.2 mg/day and 7.3 ± 4.6 mg/day, respectively. During the 1-year follow-up after treatment, there was no significant increase in CVDs in both groups. However, infections occurred in nine RS3PE patients, which is a significantly higher incidence compared to the EORA patients with infections (n= 3). The initial PSL dose was the independent variable associated with the incidence of infection. Infections were significantly increased during elderly RS3PE patients' steroid therapy. The initial corticosteroid dose was an infection-risk factor.Key messagesInfections are increased during steroid therapy in elderly patients with RS3PE syndrome.The initial dose of corticosteroids was one of the risk factors for infections.
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影响因子：
--
作者：
Doran, MF;Crowson, CS;Gabriel, SE
通讯作者：
Gabriel, SE
缓解型血清阴性对称性滑膜炎伴凹陷性水肿 (RS3PE) 病例介绍以及与影响老年人的其他多关节炎的比较。
影响因子：
6.7
作者：
Hans A Eguia;José Francisco Parodi Garcia;C. Ramas Diez;Edwin A Eguia A
通讯作者：
Edwin A Eguia A
风湿性多肌痛和缓解型血清阴性对称性滑膜炎伴凹陷性水肿综合征腕管综合征并发症的研究
DOI：
--
发表时间：
2010
期刊：
--
影响因子：
--
作者：
渡部 昌平;神崎 博允;今井 浩
通讯作者：
今井 浩
与银屑病关节炎相关的缓解型血清阴性对称性滑膜炎伴凹陷性水肿 (RS3PE)
影响因子：
2.1
作者：
S. Kardeş;M. Karagülle;N. Erdoğan
通讯作者：
N. Erdoğan