Gene therapy for lung cancer: practice and promise.
Gene therapy for lung cancer: practice and promise.
复制标题
肺癌基因治疗：实践与承诺。
DOI：
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发表时间：
2004
影响因子：
0.8
通讯作者：
Claudio Pp
中科院分区：
文献类型：
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作者：
E. Vattemi;Claudio Pp
基因治疗已成为一种令人兴奋和有前途的癌症治疗策略。随着分子生物学技术的进步和对肺癌发病机制的深入了解，各种基因被证实为基因治疗的分子靶点。在临床前研究中，人们探索了多种基因治疗策略。这些包括有缺陷的肿瘤抑制基因的替换，失活癌基因，引入自杀基因，免疫原性治疗和基于抗血管生成的方法。肺癌基因治疗的临床试验显示了递送多种药物的可行性，同时也突出了递送治疗性构建体的问题。虽然有些人可能认为这些新疗法的初步结果令人失望，但它们强调了这些方法的复杂性，以及这些方法只有在适当的临床背景下以协调的方式使用时才有效的可能性。这篇综述提供了我们目前对肺癌生物学的最新认识，并探讨了癌症基因治疗中的几个重要问题。此外，最近的临床试验结果的基因治疗肺癌。
Gene therapy has emerged as an exciting and promising strategy of cancer therapy. Improved molecular biology techniques and a greater understanding of the mechanisms involved in lung cancer pathogenesis allowed a variety of genes to be validated as molecular targets for gene therapy. A variety of gene therapy strategy have been explored in the pre-clinical research. These include replacement of defective tumor suppressor genes, inactivating oncogenes, introducing suicide genes, immunogenic therapy, and antiangiogenesis-based approach. Clinical trials of gene therapy for lung cancer showed the feasibility of delivering a variety of agent as well as highlighted problems with the delivery of therapeutic constructs. Although some may consider the initial results of these novel therapies to be disappointing, they underscore the complexity of these approaches and the likelihood that these approaches will be effective only when used in a coordinated fashion in the proper clinical context. This review provides an update on our current understanding of lung cancer biology and examines several important issues in cancer gene therapy. In addition, recent results of clinical trials of gene therapy for lung cancer are presented.