Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals
Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals
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DOI：
10.1016/j.schres.2019.03.025
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发表时间：
2019-06-01
影响因子：
4.5
通讯作者：
Spencer, Kevin M.
中科院分区：
文献类型：
--
作者：
Oribe, Naoya;Hirano, Yoji;Spencer, Kevin M.
早期听觉诱发伽玛带反应（EAGBR）可以作为听觉皮层快速反复抑制或突触连接完整性的指标，精神分裂症患者的听觉皮层存在异常现象。 EAGBR 很少在首发精神分裂症患者 (FESZ) 和精神分裂症临床高风险 (CHR) 个体中进行研究，并且从未在这些人群之间进行直接比较或纵向评估。在这里，我们在基线和 1 年随访评估中检查了 FESZ、CHR 和匹配的健康对照 (HC) 中的 EAGBR，以确定这些临床组中的 EAGBR 是否受到影响，以及是否有任何 EAGBR 异常随时间而变化。当受试者（18 FESZ、18 CHR 和 40 HC）执行一项奇怪的听觉任务时，用密集电极阵列记录脑电图。与事件相关的频谱测量（锁相因子 [PLF] 和诱发功率）是在标准试验的 Morlet 小波变换的单个历元上计算的。基线时，EAGBR PIS 和诱发功率在各组之间没有差异。与 HC 相比，FESZ 显示从基线到随访期间 PLF 和诱发功率逐渐降低，并且随访时 PLF 出现缺陷。从基线到随访，FESZ 颞区的 EAGBR 峰值频率也有所增加。在 CHR 或 HC 中未发现对 EAGBR 的纵向影响，这些组在随访中也没有差异。总之，我们在一年内检测到 FESZ 听觉皮层功能的神经生理变化，而在 CHR 中未观察到这种变化。这些发现是在精神分裂症神经发育模型的背景下讨论的。由 Elsevier B.V. 出版
The early auditory-evoked gamma band response (EAGBR) may serve as an index of the integrity of fast recurrent inhibition or synaptic connectivity in the auditory cortex, where abnormalities in individuals with schizophrenia have been consistently found. The EAGBR has been rarely investigated in first episode schizophrenia patients (FESZ) and individuals at clinical high risk (CHR) for schizophrenia, and never been compared directly between these populations nor evaluated longitudinally. Here we examined the EAGBR in FESZ, CHR, and matched healthy controls (HC) at baseline and 1-year follow-up assessments to determine whether the EAGBR was affected in these clinical groups, and whether any EAGBR abnormalities changed over time. The electroencephalogram was recorded with a dense electrode array while subjects (18 FESZ, 18 CHR, and 40 HC) performed an auditory oddball task. Event-related spectral measures (phase locking factor [PLF] and evoked power) were computed on Morlet-wavelet-transformed single epochs from the standard trials. At baseline, EAGBR PIS and evoked power did not differ between groups. FESZ showed progressive reductions of PLF and evoked power from baseline to follow-up, and deficits in PLF at follow-up compared to HC. EAGBR peak frequency also increased at temporal sites in FESZ from baseline to follow-up. Longitudinal effects on the EAGBR were not found in CHR or HC, nor did these groups differ at follow-up. In conclusion, we detected neurophysiological changes of auditory cortex function in FESZ during a one-year period, which were not observed in CHR. These findings are discussed within the context of neurodevelopmental models of schizophrenia. Published by Elsevier B.V.