The rewarding effect of aggression is reduced by nucleus accumbens dopamine receptor antagonism in mice
The rewarding effect of aggression is reduced by nucleus accumbens dopamine receptor antagonism in mice
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DOI：
10.1007/s00213-007-1054-y
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发表时间：
2008-04-01
影响因子：
3.4
通讯作者：
Kennedy, Craig H.
中科院分区：
文献类型：
--
作者：
Couppis, Maria H.;Kennedy, Craig H.
伏核(NAC)内的多巴胺(DA)受体与刺激的奖赏特性有关。攻击行为可以被强化，但NAc DA参与攻击行为的强化作用尚未得到证实。目的将DA受体拮抗剂微量注射到NAC，将其强化作用与其对攻击行为和一般运动的影响分离开来。材料与方法雄性瑞士Webster小鼠植入针对NAC的引导管，并在常驻-入侵者程序中测试攻击行为。然后，攻击性小鼠接受可变比例5(VR-5)的训练，呈现入侵者作为强化事件。D_1和D_2样受体拮抗剂SCH-23390和舒必利在小鼠按VR-5程序作出反应并攻击入侵者之前微量输注(12-50 ng)。结果SCH-23390和舒必利呈剂量依赖性地降低VR反应，但不影响旷场活动。50 ng SCH-23390剂量可抑制40%的应答率和10%的咬合行为；其他攻击行为不受影响。25和50 ng剂量的舒必利几乎完全抑制VR反应；50 ng剂量的舒必利可抑制50%的咬合反应。结论腹侧纹状体D1样受体和D2样受体均参与攻击的奖赏行为，但D1样受体可能与获得强化的动机有关，而不是攻击行为。
Rationale Dopamine (DA) receptors within the nucleus accumbens (NAc) are implicated in the rewarding properties of stimuli. Aggressive behavior can be reinforcing but the involvement of NAc DA in the reinforcing effects of aggression has yet to be demonstrated.Objective To microinject DA receptor antagonists into the NAc to dissociate their effects on reinforcement from their effects on aggressive behavior and general movement.Materials and methods Male Swiss Webster mice were implanted with guide cannulae aimed for the NAc and tested for aggressive behavior in a resident-intruder procedure. Aggressive mice were then conditioned on a variable-ratio 5 (VR-5) schedule with presentation of the intruder as the reinforcing event. The D1- and D2-like receptor antagonists SCH-23390 and sulpiride were microinfused (12-50 ng) before the mice responded on the VR-5 schedule and attacked the intruder. Open-field activity was also determined following the highest doses of these drugs.Results SCH-23390 and sulpiride dose-dependently reduced VR responding but did not affect open-field activity. The 50-ng SCH-23390 dose suppressed response rates by 40% and biting behaviors by 10%; other aggressive behaviors were not affected. The 25 and 50 ng sulpiride doses almost completely inhibited VR responding; the 50-ng dose suppressed biting by 50%.Conclusions These results suggest that both D1- and D2-like receptors in the ventral striatum are involved in the rewarding properties of aggression, but that D1-like receptors may be related to the motivation to earn reinforcement as opposed to aggressive behavior.