Evidence for stroke-induced neurogenesis in the human brain
Evidence for stroke-induced neurogenesis in the human brain
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DOI：
10.1073/pnas.0603512103
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发表时间：
2006-08-29
影响因子：
11.1
通讯作者：
Greenberg, David A.
中科院分区：
文献类型：
--
作者：
Jin, Kunlin;Wang, Xiaomei;Greenberg, David A.
啮齿动物的实验性中风刺激新生神经元从其起源部位迁移到缺血性脑区域的神经发生和迁移。我们报告说，在中风患者中，表达与新生神经元相关的标记物的细胞存在于大脑皮质梗塞周围的缺血半暗带中，这些细胞优先位于血管附近。这些发现表明，中风引起的代偿性神经发生可能发生在人脑中，它可能有助于缺血后恢复并成为中风治疗的目标。
Experimental stroke in rodents stimulates neurogenesis and migration of newborn neurons from their sites of origin into ischemic brain regions. We report that in patients with stroke, cells that express markers associated with newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where these cells are preferentially localized in the vicinity of blood vessels. These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy.