OBSERVATIONS ON DRINKING INDUCED BY HYPERTONIC SOLUTIONS
OBSERVATIONS ON DRINKING INDUCED BY HYPERTONIC SOLUTIONS
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DOI：
10.1152/ajplegacy.1950.162.2.326
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发表时间：
1950-01-01
影响因子：
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通讯作者：
GREGERSEN, MI
中科院分区：
文献类型：
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作者：
HOLMES, JH;GREGERSEN, MI
通过自愿饮水量测量的效果不仅迅速，而且可重复，具有显著的均匀性。此外，这种现象在理论上也很有趣，因为它似乎是了解口渴机制本质的最直接线索之一（1-3）。这促使我们在几年前研究这一现象，但在就我们的发现发表初步报告后不久（4），实验因战争而中断，直到最近才恢复（5，6）。本文涵盖了对狗的初步研究，涉及：I）这种形式的口渴的各种特征，只要它们可以通过饮水反应来判断，Z）用NaCl以外的晶体进行测试，以确定NaCl是否在口渴机制中具有特定功能，以及3）旨在探索高渗溶液引起口渴的机制的性质的某些实验。
The effect, as measured by the voluntary water intake, is not only prompt but reproducible with remarkable uniformity. The phenomenon is furthermore of considerable theoretical interest, because it appears to be one of the most direct clues to the nature of the mechanism of thirst (1-3). This prompted us several years ago to study the phenomenon but soon after delivering a preliminary report on our findings (4) the experiments were interrupted by the war and have only recently been resumed (5, 6). The present paper, covering the initial studies on dogs deals with I) various characteristics of this form of thirst so far as they can be judged by the drinking response, z) tests with crystalloids other than NaCl to determine whether or not NaCl has a specific function in the thirst mechanism, and 3) certain experiments designed to explore the nature of the mechanism by which hypertonic solutions cause thirst.